ReviewNature reviews. Rheumatology2013
Diffuse idiopathic skeletal hyperostosis: clinical features and pathogenic mechanisms.
Review in Nature reviews. Rheumatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03237455 (Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis), which is not on this map. Cited by 128 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
Who cites it
128 citing papers in PubMed, 1 synthesis or guideline pooled it, 269 citations in OpenAlex.
- Global prevalence estimates of diffuse idiopathic skeletal hyperostosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Diffuse Idiopathic Skeletal Hyperostosis (DISH) With Cervical Myelopathy: A Case Report From Sudan.Clinical case reports · 2026Article
- Association of diffuse idiopathic skeletal hyperostosis with postoperative outcomes following surgery for degenerative lumbar spine disease.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The relation between cardiovascular calcifications and diffuse idiopathic skeletal hyperostosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Severe Aerodigestive Compromise Caused by Cervical Diffuse Idiopathic Skeletal Hyperostosis: A Case Report.Journal of orthopaedic case reports · 2026Article
- The prevalence of ENPP1 deficiency in humans with Ossification of the Posterior Longitudinal Ligament and the preclinical efficacy of ENPP1 enzyme therapy in murine Ossification of the Posterior Longitudinal Ligament.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Dysphagia Secondary to Cervical Hyperostosis in Diffuse Idiopathic Skeletal Hyperostosis: A Case Report.Cureus · 2026Article
- Cervical DISH, is there any place for multilevel cervical arthroplasty? A case report metal-on-metal two-level cervical disc arthroplasty with 2-year follow-up and quality of life assessment.International journal of surgery case reports · 2026Article
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- Multi-Level Uncinatectomies and Posterior Column Osteotomies to Correct a Cervical Kyphotic Deformity: Case Instruction With Intraoperative Picture and Video.Neurosurgery practice · 2026Article
- Non-cervical diffuse idiopathic skeletal hyperostosis is a risk factor for severe cervical spinal cord injury.BMC musculoskeletal disorders · 2026Article
- Case of spontaneous regression of DISH-associated retro-odontoid pannus following occipto-cervical fusion.Surgical neurology international · 2026Article
- Late-onset ankylosing spondylitis presenting with severe flank and abdominal-to-back pain in a 64-year-old man: a case report.AME case reports · 2026Article
- Genetics and pathophysiology of diffuse idiopathic skeletal hyperostosis.Frontiers in endocrinology · 2026Review
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- Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.Frontiers in surgery · 2026Article
- Whole Spine and Sacroiliac Joint MRI of Patients With and Without Metabolic Syndrome: A Preliminary Study.Diagnostics (Basel, Switzerland) · 2025Article
- Distinguishing bone marrow edema patterns on MRI between spondyloarthritis and diffuse idiopathic skeletal hyperostosis.BMC medical imaging · 2025Article
- Influence of Spinal Bridging Ossification on Mechanical Properties and Fracture Tolerance Under Flexion/Extension Loading.Annals of biomedical engineering · 2025Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition characterized by the ossification and calcification of ligaments and entheses. DISH is observed on all continents and in all races, but most commonly in men over 50 years of age. Although DISH is asymptomatic in most individuals, the condition is often an indicator of underlying metabolic disease, and the presence of spinal or extraspinal ossifications can sometimes lead to symptoms including pain, stiffness, a reduced range of articular motion, and dysphagia, as well as increasing the risk of unstable spinal fractures. The aetiology of DISH is poorly understood, and the roles of the many factors that might be involved in the development of excess bone are not well delineated. The study of pathophysiological aspects of DISH is made difficult by the formal diagnosis requiring the presence of multiple contiguous fully formed bridging ossifications, which probably represent advanced stages of DISH. In this Review, the reader is provided with an up-to-date discussion of the epidemiological, aetiological and clinical aspects of DISH. Existing classification criteria (which, in the absence of diagnostic criteria, are used to establish a diagnosis of DISH) are also considered, together with the need for modified criteria that enable timely identification of early phases in the development of DISH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.