ReviewNature reviews. Nephrology2013
Orthostatic hypertension-a new haemodynamic cardiovascular risk factor.
Review in Nature reviews. Nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03496792 (The Venous Distension Reflex and Orthostatic Hypertension), which is not on this map. Cited by 64 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Venous Distension Reflex and Orthostatic Hypertension
Who cites it
64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- A Review of Clinical Trial and Meta-Analyses of BP Treatment Strategies for Patients with Orthostatic Hypotension: Blood Pressure Management in Patients with Hypertension and Orthostatic Hypotension.Current hypertension reports · 2026Pooled it
- Patient-Specific Factors Predicting Renal Denervation Response in Patients With Hypertension: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2024Pooled it
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019Guideline
- Orthostatic hypertension: From pathophysiology to clinical applications and therapeutic considerations.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- Association of orthostatic hypertension with mortality in the Systolic Hypertension in the Elderly Program.Journal of human hypertension · 2019Trial
- Orthostatic changes in systolic blood pressure among SPRINT participants at baseline.Journal of the American Society of Hypertension : JASH · 2016Trial
- Resting skin sympathetic nerve activity spectral characteristics are associated with orthostatic sympathetic responses and exaggerated orthostatic pressor response in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Overcoming variable response in renal denervation: Key strategies for reliable clinical implementation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Supine hypertension: hemodynamic and neurohumoral mechanisms-reflections on the hypertension research update and perspectives 2025.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association of orthostatic hypertension identified according to different definitions with cardiovascular disease. The PARTAGE study.Journal of hypertension · 2026Article
- Blood Pressure Postural Changes Variability Is Associated With Lower Cognition: The S.AGES Cohort.Journal of the American Heart Association · 2025Article
- The relationship between physical activity, orthostatic blood pressure reactions and subclinical atherosclerosis: the Swedish CArdioPulmonary bioImage Study (SCAPIS).Journal of human hypertension · 2025Article
- Impact of scheduled water intake on mild cognitive impairment in patients with orthostatic hypotension.Scientific reports · 2025Article
- Artificial intelligence driven clustering of blood pressure profiles reveals frailty in orthostatic hypertension.Experimental physiology · 2025Article
- The role of peripheral venous distension reflex in regulating hemodynamics: mini review.Autonomic neuroscience : basic & clinical · 2024Review
- What are the ideal metrics for assessing the quality of long-term stabilized "perfect" 24-h BP control after renal denervation?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Orthostatic hypotension, orthostatic hypertension, and ambulatory blood pressure in patients with chronic kidney disease in CRIC.Journal of hypertension · 2024Observational
- The physiologic complexity of beat-to-beat blood pressure is associated with age-related alterations in blood pressure regulation.Aging cell · 2024Article
- Orthostatic Hypertension: A Newcomer Among the Hypertension Phenotypes.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Short-chain fatty acids in diseases.Cell communication and signaling : CCS · 2023Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthostatic hypertension-a condition characterized by a hyperactive pressor response to orthostatic stress-is an emerging risk factor for cardiovascular disease and is associated with hypertensive target-organ damage (resulting in silent cerebrovascular disease, left ventricular hypertrophy, carotid atherosclerosis and/or chronic kidney disease) and cardiovascular events (such as coronary artery disease and lacunar stroke). The condition is also considered to be a form of prehypertension as it precedes hypertension in young, normotensive adults. Orthostatic blood pressure changes can be assessed using orthostatic stress tests, including clinic active standing tests, home blood pressure monitoring and the head-up tilting test. Devices for home and for ambulatory blood pressure monitoring that are equipped with position sensors and do not induce a white-coat effect have increased the sensitivity and specificity of diagnosis of out-of-clinic orthostatic hypertension. Potential major mechanisms of orthostatic hypertension are sympathetic hyperactivity (as a result of hypersensitivity of the cardiopulmonary and arterial baroreceptor reflex) and α-adrenergic hyperactivation. Orthostatic hypertension is also associated with morning blood pressure surge and extreme nocturnal blood pressure dipping, both of which increase the pulsatile haemodynamic stress of central arterial pressure and blood flow in patients with systemic haemodynamic atherothrombotic syndrome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.