Evidence map›Paper›PMID 24188980›Full record

ReviewExercise and sport sciences reviews2014

Electron paramagnetic resonance resolves effects of oxidative stress on muscle proteins.

Rebecca J Moen, Jennifer C Klein, David D Thomas

Abstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Aging of skeletal muscle fibers.Annals of rehabilitation medicine · 2015
    Review
  10. Review
  11. Redox-sensitive residue in the actin-binding interface of myosin.Biochemical and biophysical research communications · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rebecca J Moen1Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN; 2Department of Chemistry and Geology, Minnesota State University, Mankato, Mankato, MN; and 3Department of Biology, University of Wisconsin, Lacrosse, Lacrosse, WI.
Jennifer C Klein
David D Thomas

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Structural Dynamics of Muscle ContractionR01AR032961 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 1986 to 2018
$8.0M
Site-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5M
Use of specific transcription factors to promote limb regeneration capacityP30AR057220 · NIAMS · UNIVERSITY OF MINNESOTA · PI PERRIN, BENJAMIN J · 2009 to 2013
$3.0M
Protein Oxidation, Structure, &Function in Aging MuscleR01AG026160 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 2004 to 2008
$2.2M
MOLECULAR DYNAMICS OF MUSCLE CONTRACTIONR37AR032961 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID DALE · 1994 to 2003
$2.1M
Spectroscopic Probes of the Muscle CytoskeletonR01AR063007 · NIAMS · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2012 to 2015
$1.3M
Structural and functional effects of site-directed oxidative modification of myosF31AG037303 · NIA · UNIVERSITY OF MINNESOTA · PI MOEN, REBECCA J · 2010 to 2013
$111k
NIAMS NIH HHS AR057220NIAMS NIH HHS AR32961NIAMS NIH HHS P30 AR057220NIAMS NIH HHS R01 AR032961NIAMS NIH HHS R01 AR063007NIAMS NIH HHS R37 AR032961NIAMS NIH HHS T32 AR007612NIA NIH HHS AG037303NIA NIH HHS AG26160NIA NIH HHS F31 AG037303NIA NIH HHS R01 AG026160NIA NIH HHS R37 AG026160
6 · The paper itself

Abstract

We have used site-directed spin labeling and electron paramagnetic resonance (EPR) to explore the effects of oxidation on muscle function, with particular focus on the actin-myosin interaction. EPR measurements show that aging or oxidative modification causes a decrease in the fraction of myosins in the strong-binding state, which can be traced to the actin-binding cleft of the myosin catalytic domain.

Indexed as

Oxidative StressActomyosinAgingAnimalsElectron Spin Resonance SpectroscopyMethionineMyosinsActomyosinMethionineMyosins

Identifiers

PMID24188980
PMCPMC3934098

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.