Evidence map›Paper›PMID 24188978›Full record

ReviewExercise and sport sciences reviews2014

MRI reveals brain abnormalities in drug-naive Parkinson's disease.

Peggy J Planetta, Nikolaus R McFarland, Michael S Okun, David E Vaillancourt

Abstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peggy J PlanettaDepartments of 1Applied Physiology and Kinesiology, and 2Neurology, 3Center for Movement Disorders and Neurorestoration, and Departments of 4Neurosurgery, and 5Biomedical Engineering, University of Florida, Gainesville, FL.
Nikolaus R McFarland
Michael S Okun
David E Vaillancourt

Funding

Role of the Cortex and Cerebellum in Visually-Guided Motor BehaviorR01NS058487 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAFFEE, MICHAEL S., VAILLANCOURT, DAVID E · 2008 to 2025
$6.1M
Scaling and Sequencing Motor Output in Humans: fMRI StudyR01NS052318 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VAILLANCOURT, DAVID E · 2005 to 2020
$6.0M
Non-Invasive Markers of Neurodegeneration in Movement DisordersR01NS075012 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING, VAILLANCOURT, DAVID E · 2012 to 2022
$4.1M
Rab proteins and alpha-Synuclein toxicity in Neurodegenerative DiseaseK08NS067024 · NINDS · UNIVERSITY OF FLORIDA · PI MCFARLAND, NIKOLAUS RENZ · 2010 to 2014
$904k
NINDS NIH HHS K08 NS067024NINDS NIH HHS R01 NS052318NINDS NIH HHS R01 NS058487NINDS NIH HHS R01 NS075012NINDS NIH HHS R01-NS-075012NINDS NIH HHS R01-NS-52318NINDS NIH HHS R01-NS-58487
6 · The paper itself

Abstract

Most brain studies of Parkinson's disease (PD) focus on patients who are already taking antiparkinsonian medication. This makes it difficult to isolate the effects of disease from those of treatment. We review magnetic resonance imaging evidence supporting the hypothesis that early-stage untreated PD patients have structural and functional abnormalities in the brain, some of which are related to motor symptoms.

Indexed as

BrainHumansMagnetic Resonance ImagingParkinson DiseasePsychomotor Performance

Identifiers

PMID24188978
PMCPMC3885158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.