Evidence map›Paper›PMID 24188511›Full record

Trial reportJournal of consulting and clinical psychology2014

A randomized trial of family focused therapy with populations at clinical high risk for psychosis: effects on interactional behavior.

Mary P O'Brien, David J Miklowitz, Kristin A Candan, Catherine Marshall, Isabel Domingues, Barbara C Walsh, Jamie L Zinberg, Sandra D De Silva, Kristen A Woodberry, Tyrone D Cannon

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of consulting and clinical psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04338152 (Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04338152 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2021 to 2026Enrolled220ConditionsPsychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, PsychosisArmsFamily Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC)
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Interventions for prodromal stage of psychosis.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Trajectories of parent criticism across treatment for youth self-harm.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Trial
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  11. Family communication with teens at clinical high-risk for psychosis or bipolar disorder.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2018
    Trial
  12. Decreases in perceived maternal criticism predict improvement in subthreshold psychotic symptoms in a randomized trial of family-focused therapy for individuals at clinical high risk for psychosis.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Mary P O'BrienDepartment of Psychiatry, University of California, Los Angeles, School of Medicine.
David J MiklowitzDepartment of Psychiatry, University of California, Los Angeles, School of Medicine.
Kristin A CandanDivision of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System.
Catherine MarshallHotchkiss Brain Institute, Department of Psychiatry, University of Calgary.
Isabel DominguesDepartment of Psychiatry, University of California, San Diego.
Barbara C WalshDepartment of Psychiatry, Yale University School of Medicine.
Jamie L ZinbergDepartment of Psychology, University of California, Los Angeles.
Sandra D De SilvaCenter for the Assessment and Prevention of Prodromal States, University of California, Los Angeles.
Kristen A WoodberryBeth Israel Deaconess Medical Center, Harvard Medical School.
Tyrone D CannonDepartment of Psychiatry and Department of Psychology, University of California, Los Angeles.
University of California, Los Angeles · USAllen Institute for Brain Science · USCenter for Assessment · USHadassah Medical Center · ILNorthwell Health · USUniversity of California San Diego · USYale University · US

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Prevention Trial of Family Focused Treatment in Youth at Risk for PsychosisRC1MH088546 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CANNON, TYRONE D · 2009 to 2010
$970k
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007NIMH NIH HHS RC1 MH088546
6 · The paper itself

Abstract

objectiveThis study investigated whether family focused therapy (FFT-CHR), an 18-session intervention that consisted of psychoeducation and training in communication and problem solving, brought about greater improvements in family communication than enhanced care (EC), a 3-session psychoeducational intervention, among individuals at clinical high risk for developing psychosis.

methodThis study was conducted within a randomized controlled trial across 8 sites. We examined 10-min problem-solving discussions at baseline and 6-month reassessment among 66 adolescents and young adults and their parents. Trained coders who were blind to treatment and time of assessment achieved high levels of interrater reliability when evaluating family discussions on categories of calm-constructive and critical-conflictual behavior.

resultsIndividuals at high risk and their family members who participated in FFT-CHR demonstrated greater improvement from baseline to 6-month reassessment in constructive communication and decreases in conflictual behaviors during family interactions than those in EC. Participants in FFT-CHR showed greater increases from baseline to 6 months in active listening and calm communication and greater decreases in irritability and anger, complaints and criticism, and off-task comments compared to participants in EC. These changes occurred equally in high-risk participants and their family members.

conclusionsA 6-month family skills training treatment can bring about significant improvement in family communication among individuals at high risk for psychosis and their parents. Future studies should examine the association between enhancements in family communication and reduced risk for the onset of psychosis among individuals at high risk.

Indexed as

CommunicationProblem SolvingAdolescentFamilyFamily TherapyFemaleHumansMalePsychotic DisordersTreatment OutcomeYoung Adult

Identifiers

PMID24188511
PMCPMC3909734
OpenAlexW2157173545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.