ArticleLipids in health and disease2013
Probucol inhibits the initiation of atherosclerosis in cholesterol-fed rabbits.
Article in Lipids in health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Probucol: revisiting as a multifaceted therapeutic agent in atherosclerosis.Frontiers in pharmacology · 2025Review
- Examining atherosclerotic lesions in three dimensions at the nanometer scale with cryo-FIB-SEM.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A cynomolgus monkey model of carotid atherosclerosis induced by puncturing and scratching of the carotid artery combined with a high-fat diet.Experimental and therapeutic medicine · 2018Article
- Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Combination of rosuvastatin and probucol inhibits MMP-9 expression via upregulation of miR-497 in cultured HUVECs and apoE knockout mice.Journal of thrombosis and thrombolysis · 2016Article
- The hematologic effects of low intensity 650 nm laser irradiation on hypercholesterolemia rabbits.American journal of translational research · 2016Article
- Effects of rosuvastatin combined with fasudil therapy on rabbits with dyslipidemia.Lipids in health and disease · 2015Article
- The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets.International journal of molecular sciences · 2015Article
- Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine.Pharmacology & therapeutics · 2015Review
- Article
- Atorvastatin combined with poly-unsaturated fatty acid confers better improvement of dyslipidemia and endothelium function.Lipids in health and disease · 2014Article
- Terminalia paniculata bark extract attenuates non-alcoholic fatty liver via down regulation of fatty acid synthase in high fat diet-fed obese rats.Lipids in health and disease · 2014Article
- Time course-changes in phosphatidylcholine profile during oxidative modification of low-density lipoprotein.Lipids in health and disease · 2014Article
- Add-on effect of probucol in atherosclerotic, cholesterol-fed rabbits treated with atorvastatin.PloS one · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProbucol and statin are often prescribed for treating atherosclerosis. These two drugs exhibit different mechanisms but it is unknown whether they have the same anti-atherogenic properties. In the current study, we examined whether these two drugs at optimal doses could inhibit the initiation of atherosclerosis in cholesterol-fed rabbits in the same way.
methodsNew Zealand White rabbits were fed a cholesterol-rich diet for 5 weeks to produce the early-stage lesions of atherosclerosis. Drug-treated rabbits were administered either probucol or atorvastatin and serum lipids and aortic atherosclerotic lesions were compared with those in a control group.
resultsAtorvastatin treatment significantly reduced serum total cholesterol levels while probucol treatment led to significant reduction of high-density lipoprotein cholesterol levels without changing total cholesterol levels compared with those in the control group. Compared with the control, probucol treatment led to 65% (p < 0.01) reduction while atorvastatin treatment led to 23% (p = 0.426) reduction of the aortic lesion area. Histological and immunohistochemical analyses revealed that the lesions of the probucol-treated group were characterized by remarkable reduction of monocyte adherence to endothelial cells and macrophage accumulation in the intima compared with those of both atorvastatin and control groups. Furthermore, low-density lipoprotein (LDL) isolated from the probucol group exhibited prominent anti-oxidative reaction, which was not present in LDL isolated from either the atorvastatin-treated or the control group.
conclusionsThis study suggests that probucol inhibits the initiation of atherosclerosis by reducing monocyte adherence and infiltration into the subintima. Anti-oxidization of LDL by probucol protects more effectively against early-stage lesion formation than statin-mediated lipid-lowering effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.