ReviewPathogens and global health2013
Microbial symbiosis and the control of vector-borne pathogens in tsetse flies, human lice, and triatomine bugs.
Review in Pathogens and global health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Bacterial Symbionts Associated with Wild Tsetse Flies (Diptera: Glossinidae) in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Baseline Characterization of the Gut Microbiota of Field and Colony Populations ofPathogens (Basel, Switzerland) · 2026Article
- Detection and Genetic Diversity of Heritable Bacterial Symbionts in Human Lice Based on 16S-rRNA Gene.Environmental microbiology reports · 2026Article
- Article
- Comparative Community Ecology Reveals Conserved Ectoparasite Microbiomes Amidst Variable Host and Environment Microbiomes.Ecology and evolution · 2025Article
- Effect ofEcology and evolution · 2024Article
- Article
- Cascading effects of habitat loss on ectoparasite-associated bacterial microbiomes.ISME communications · 2022Article
- Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors.Parasites & vectors · 2022Review
- Phylogenetic relationship between the endosymbiont "Candidatus Riesia pediculicola" and its human louse host.Parasites & vectors · 2022Article
- The Role of Bacterial Symbionts in Triatomines: An Evolutionary Perspective.Microorganisms · 2020Review
- Dynamic of Composition and Diversity of Gut Microbiota inFrontiers in cellular and infection microbiology · 2020Article
- Where Are We With Human Lice? A Review of the Current State of Knowledge.Frontiers in cellular and infection microbiology · 2019Review
- Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods.Parasites & vectors · 2018Article
- A Coxiella mutualist symbiont is essential to the development of Rhipicephalus microplus.Scientific reports · 2017Article
- Genotype specificity among hosts, pathogens, and beneficial microbes influences the strength of symbiont-mediated protection.Evolution; international journal of organic evolution · 2017Article
- Grandeur Alliances: Symbiont Metabolic Integration and Obligate Arthropod Hematophagy.Trends in parasitology · 2016Review
- A Coxiella-like endosymbiont is a potential vitamin source for the Lone Star tick.Genome biology and evolution · 2015Article
- Conservation Biological Control of Pests in the Molecular Era: New Opportunities to Address Old Constraints.Frontiers in plant science · 2015Review
- Challenges posed by tick-borne rickettsiae: eco-epidemiology and public health implications.Frontiers in public health · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symbiosis is a widespread biological phenomenon, and is particularly common in arthropods. Bloodsucking insects are among the organisms that rely on beneficial bacterial symbionts to complement their unbalanced diet. This review is focused on describing symbiosis, and possible strategies for the symbiont-based control of insects and insect-borne diseases, in three bloodsucking insects of medical importance: the flies of the genus Glossina, the lice of the genus Pediculus, and triatomine bugs of the subfamily Triatominae. Glossina flies are vector of Trypanosoma brucei, the causative agent of sleeping sickness and other pathologies. They are also associated with two distinct bacterial symbionts, the primary symbiont Wigglesworthia spp., and the secondary, culturable symbiont Sodalis glossinidius. The primary symbiont of human lice, Riesia pediculicola, has been shown to be fundamental for the host, due to its capacity to synthesize B-group vitamins. An antisymbiotic approach, with antibiotic treatment targeted on the lice symbionts, could represent an alternative strategy to control these ectoparasites. In the case of triatominae bugs, the genetic modification of their symbiotic Rhodococcus bacteria, for production of anti-Trypanosoma molecules, is an example of paratransgenesis, i.e. the use of symbiotic microorganism engineered in order to reduce the vector competence of the insect host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.