ArticleExperimental and clinical psychopharmacology2014
The effects of methylphenidate on cerebral activations to salient stimuli in healthy adults.
Article in Experimental and clinical psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Methylphenidate differentially alters corticostriatal connectivity after traumatic brain injury.Brain : a journal of neurology · 2025Trial
- Catecholaminergic Modulation of Conflict Control Depends on the Source of Conflicts.The international journal of neuropsychopharmacology · 2018Trial
- Waiting Impulsivity: The Influence of Acute Methylphenidate and Feedback.The international journal of neuropsychopharmacology · 2015Trial
- Methylphenidate Ameliorates Behavioural and Neurobiological Deficits in Executive Function for Patients with Chronic Traumatic Brain Injury.Journal of clinical medicine · 2024Article
- A randomized, double-blind, placebo-controlled clinical trial of 8-week intranasal oxytocin administration in adults with obesity: Rationale, study design, and methods.Contemporary clinical trials · 2022Article
- Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations.Psychopharmacology · 2020Article
- An information network flow approach for measuring functional connectivity and predicting behavior.Brain and behavior · 2019Article
- Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder.Translational psychiatry · 2019Article
- Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction.Drug and alcohol dependence · 2018Article
- Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease.Neurobiology of aging · 2018Article
- Connectome-based predictive modeling of attention: Comparing different functional connectivity features and prediction methods across datasets.NeuroImage · 2018Article
- Characterizing Attention with Predictive Network Models.Trends in cognitive sciences · 2017Review
- Response inhibition in Parkinson's disease: a meta-analysis of dopaminergic medication and disease duration effects.NPJ Parkinson's disease · 2017Review
- Methylphenidate Modulates Functional Network Connectivity to Enhance Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task.Journal of psychopharmacology (Oxford, England) · 2016Article
- The Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults.Frontiers in human neuroscience · 2016Article
- Anticipating conflict: Neural correlates of a Bayesian belief and its motor consequence.NeuroImage · 2015Article
- Independent component analysis of functional networks for response inhibition: Inter-subject variation in stop signal reaction time.Human brain mapping · 2015Article
- The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults.The international journal of neuropsychopharmacology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Detection of a salient stimulus is critical to cognitive functioning. A stimulus is salient when it appears infrequently, carries high motivational value, and/or when it dictates changes in behavior. Individuals with neurological conditions that implicate altered catecholaminergic signaling, such as those with attention deficit hyperactivity disorder, are impaired in detecting salient stimuli, a deficit that can be remediated by catecholaminergic medications. However, the effects of these catecholaminergic agents on cerebral activities during saliency processing within the context of the stop-signal task are not clear. Here, we examined the effects of a single oral dose (45 mg) of methylphenidate in 24 healthy adults performing the stop-signal task during functional MRI (fMRI). Compared to 92 demographically matched adults who did not receive any medications, the methylphenidate group showed higher activations in bilateral caudate head, primary motor cortex, and the right inferior parietal cortex during stop as compared to go trials (p < .05, corrected for family-wise error of multiple comparisons). These results show that methylphenidate enhances saliency processing by promoting specific cerebral regional activities. These findings may suggest a neural basis for catecholaminergic treatment of attention disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.