ArticleNeuropsychology2014
Nonlinear longitudinal trajectories of cholesterol and neuropsychological function.
Article in Neuropsychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis.Journal of Alzheimer's disease : JAD · 2017Pooled it
- Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.European archives of psychiatry and clinical neuroscience · 2026Article
- Dyslipidemia and cerebral atrophy among health check-up individuals: A cross-sectional study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Article
- Higher Total Cholesterol Concentration May Be Associated with Better Cognitive Performance among Elderly Females.Nutrients · 2022Article
- Sex Differences in the Association Between Metabolic Dysregulation and Cognitive Aging: The Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Article
- Association between metabolic syndrome and resting-state functional brain connectivity.Neurobiology of aging · 2021Article
- The Relationship Between Cardiovascular Health and Rate of Cognitive Decline in Young-Old and Old-Old Adults: A Population-Based Study.Journal of Alzheimer's disease : JAD · 2021Article
- Low Cholesterol Level Linked to Reduced Semantic Fluency Performance and Reduced Gray Matter Volume in the Medial Temporal Lobe.Frontiers in aging neuroscience · 2020Article
- Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study.Molecular neurodegeneration · 2019Article
- "Exceptional brain aging" without Alzheimer's disease: triggers, accelerators, and the net sum game.Alzheimer's research & therapy · 2018Article
- Nonlinear associations between plasma cholesterol levels and neuropsychological function.Neuropsychology · 2016Article
- Increased attrition of leukocyte telomere length in young adults is associated with poorer cognitive function in midlife.European journal of epidemiology · 2016Article
- Cardiovascular Risk Factors and Cognitive Performance in Cognitively Normal Non-Hispanic Whites and Mexican Americans From the HABS-HD Cohort.Gerontology & geriatric medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
objectivePrior literature has identified inconsistent longitudinal associations between total cholesterol and cognitive decline. The authors examined prospective nonlinear relations of coincident trajectories of total cholesterol and cognitive function among persons free of stroke, dementia, and other neurological disease.
methodUp to 1,601 participants from the Baltimore Longitudinal Study of Aging (aged 19-93, 51% male, 75% White) underwent fasting cholesterol measurement and neuropsychological assessment on up to 12 occasions (M = 3.2, SD = 2.1) over up to 19 years (M = 6.4, SD = 5.3) of follow-up. Mixed-effects regression analyses were adjusted for age, sex, race, education, systolic blood pressure, body mass index, cardiovascular disease, lipid-lowering medication use, smoking, alcohol use, and depressive symptoms.
resultsAnalyses revealed significant longitudinal associations between quadratic total cholesterol and performance on measures of global mental status, verbal learning, executive function, and language (all ps < .05). In general, higher total cholesterol was associated with poorer middle-aged or young-old (60-69 years) cognitive performance, but better old-old (80-89 years) cognitive performance. Linear models also revealed an association between lower total cholesterol and accelerated decline in visual memory performance.
conclusionsOverall, results indicate nonlinear longitudinal relations of total cholesterol to cognitive decline. Whereas higher cholesterol levels were associated with cognitive decline in the middle-aged or young-old, lower cholesterol levels were related to cognitive decline among old-old participants.
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