ArticleDrug discovery today. Disease models2013
Fish in a Dish: Drug Discovery for Hearing Habilitation.
Article in Drug discovery today. Disease models, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds.International journal of molecular sciences · 2025Review
- Effects of 'Perinatal Risk Factors Associated with Hearing Loss' on Auditory Outcomes in Cochlear Implant Recipient Children.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Localization of Neurotrophin Specific Trk Receptors in Mechanosensory Systems of Killifish (International journal of molecular sciences · 2021Article
- A versatile, automated and high-throughput drug screening platform for zebrafish embryos.Biology open · 2021Article
- Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death.Frontiers in cellular neuroscience · 2020Article
- Structure Characterization and Otoprotective Effects of a New Endophytic Exopolysaccharide from Saffron.Molecules (Basel, Switzerland) · 2019Article
- Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells.Frontiers in cellular neuroscience · 2019Article
- Inner Workings: Zebrafish assay forges new approach to drug discovery.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues.NPJ Regenerative medicine · 2018Article
- SS-31 peptide enables mitochondrial targeting drug delivery: a promising therapeutic alteration to prevent hair cell damage from aminoglycosides.Drug delivery · 2017Article
- Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells.The Journal of clinical investigation · 2017Article
- Congenital hearing loss.Nature reviews. Disease primers · 2017Review
- Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death.The Journal of clinical investigation · 2016Article
- Advancements in zebrafish applications for 21st century toxicology.Pharmacology & therapeutics · 2016Review
- Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish.Frontiers in pharmacology · 2016Article
- Natural Bizbenzoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside Toxicity.Frontiers in cellular neuroscience · 2016Article
- Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing.Neurobiology of aging · 2015Article
- Sensory hair cell death and regeneration in fishes.Frontiers in cellular neuroscience · 2015Review
- Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure.Frontiers in cellular neuroscience · 2015Article
- Sensory hair cell regeneration in the zebrafish lateral line.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The majority of hearing loss is caused by the permanent loss of inner ear hair cells. The identification of drugs that modulate the susceptibility to hair cell loss or spur their regeneration is often hampered by the difficulties of assaying for such complex phenomena in mammalian models. The zebrafish has emerged as a powerful animal model for chemical screening in many contexts. Several characteristics of the zebrafish, such as its small size and external location of sensory hair cells, uniquely position it as an ideal model organism for the study of hair cell toxicity, protection, and regeneration. We have used this model to screen for drugs that affect each of these aspects of hair cell biology and have identified compounds that affect each of these processes. The identification of such drugs and drug-like compounds holds promise in the future ability to stem hearing loss in the human population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.