ArticleFrontiers in systems neuroscience2013
Apis mellifera octopamine receptor 1 (AmOA1) expression in antennal lobe networks of the honey bee (Apis mellifera) and fruit fly (Drosophila melanogaster).
Article in Frontiers in systems neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 44 citations in OpenAlex.
- Octopamine and tyramine dynamics predict learning rate phenotypes during associative conditioning in honey bees.Science advances · 2026Article
- Plasticity in inhibitory networks improves pattern separation in early olfactory processing.Communications biology · 2025Article
- Tyramine and itseLife · 2023Article
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- The octopamine receptor OAα1 influences oogenesis and reproductive performance in Rhodnius prolixus.PloS one · 2023Article
- In Search for the Retrievable Memory Trace in an Insect Brain.Frontiers in systems neuroscience · 2022Review
- Olfactory coding in honeybees.Cell and tissue research · 2021Review
- Experience-dependent tuning of early olfactory processing in the adult honey bee,The Journal of experimental biology · 2020Article
- Comparative study of chemical neuroanatomy of the olfactory neuropil in mouse, honey bee, and human.Biological cybernetics · 2018Article
- Morphofunctional experience-dependent plasticity in the honeybee brain.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Olfactory learning without the mushroom bodies: Spiking neural network models of the honeybee lateral antennal lobe tract reveal its capacities in odour memory tasks of varied complexities.PLoS computational biology · 2017Article
- The Biogenic Amine Tyramine and its Receptor (AmTyr1) in Olfactory Neuropils in the Honey Bee (Frontiers in systems neuroscience · 2017Article
- Learning about natural variation of odor mixtures enhances categorization in early olfactory processing.The Journal of experimental biology · 2016Article
- Article
- Learning modifies odor mixture processing to improve detection of relevant components.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Editorial: Reward- and aversion-related processing in the brain: translational evidence for separate and shared circuits.Frontiers in systems neuroscience · 2015Article
- Computational models to understand decision making and pattern recognition in the insect brain.Current opinion in insect science · 2014Article
- Data-driven inference of network connectivity for modeling the dynamics of neural codes in the insect antennal lobe.Frontiers in computational neuroscience · 2014Article
- Differences in the phototaxis of pollen and nectar foraging honey bees are related to their octopamine brain titers.Frontiers in physiology · 2014Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
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Abstract
Octopamine (OA) underlies reinforcement during appetitive conditioning in the honey bee and fruit fly, acting via different subtypes of receptors. Recently, antibodies raised against a peptide sequence of one honey bee OA receptor, AmOA1, were used to study the distribution of these receptors in the honey bee brain (Sinakevitch et al., 2011). These antibodies also recognize an isoform of the AmOA1 ortholog in the fruit fly (OAMB, mushroom body OA receptor). Here we describe in detail the distribution of AmOA1 receptors in different types of neurons in the honey bee and fruit fly antennal lobes. We integrate this information into a detailed anatomical analysis of olfactory receptor neurons (ORNs), uni- and multi-glomerular projection neurons (uPNs, and mPNs) and local interneurons (LNs) in glomeruli of the antennal lobe. These neurons were revealed by dye injection into the antennal nerve, antennal lobe, medial and lateral antenno-protocerbral tracts (m-APT and l-APT), and lateral protocerebral lobe (LPL) by use of labeled cell lines in the fruit fly or by staining with anti-GABA. We found that ORN receptor terminals and uPNs largely do not show immunostaining for AmOA1. About seventeen GABAergic mPNs leave the antennal lobe through the ml-APT and branch into the LPL. Many, but not all, mPNs show staining for AmOA1. AmOA1 receptors are also in glomeruli on GABAergic processes associated with LNs. The data suggest that in both species one important action of OA in the antennal lobe involves modulation of different types of inhibitory neurons via AmOA1 receptors. We integrated this new information into a model of circuitry within glomeruli of the antennal lobes of these species.
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