Evidence map›Paper›PMID 24187469›Full record

SynthesisWorld journal of gastroenterology2013

Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis.

Yan-Yan Ma, Lin Li, Chao-Hui Yu, Zhe Shen, Li-Hua Chen, You-Ming Li

3 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 166 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 20 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02764047 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Effect of Probiotics in the Treatment of Nonalcoholic Fatty Liver Disease

TypeinterventionalSponsorFederal University of Health Science of Porto AlegreRan2015 to 2018Enrolled58ConditionsNon-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, Fatty Liver, Nonalcoholic, NAFLDArmsProbiotic
NCT03664596 nacompletednot on this mapstarted 2018, after this paper: background citation

Evaluation Of The Therapeutic And Dietary Properties Of The Sublimated Mare's Milk Supplement In Patients With Non-Alcoholic Steatohepatitis

TypeinterventionalSponsorMedical Centre Hospital of the President's Affairs Administration, Republic of KazakhstanRan2018 to 2020Enrolled80ConditionsNon-alcoholic SteatohepatitisArmsSublimated mare's milk, Ursodeoxycholic Acid
NCT04823676 nacompletednot on this mapstarted 2021, after this paper: background citation

Efficacy and Safety of a Probiotic Composition as Adjunct Treatment in the Comprehensive Management of Metabolism-Associated Hepatic Steatosis in Adults

TypeinterventionalSponsorAB Biotics, SARan2021 to 2022Enrolled100ConditionsNon Alcoholic Fatty LiverArmsProbiotic composition, Placebo
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 20 syntheses or guidelines pooled it, 351 citations in OpenAlex.

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  3. Efficacy of interventions with live combinedFrontiers in pharmacology · 2025
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  13. THE THERAPEUTIC IMPACT OF PROBIOTICS ON NONALCOHOLIC FATTY LIVER DISEASE IN PEDIATRICS: A SYSTEMATIC REVIEW.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2021
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  19. Probiotics for people with hepatic encephalopathy.The Cochrane database of systematic reviews · 2017
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yan-Yan MaYan-Yan Ma, Lin Li, Chao-Hui Yu, Zhe Shen, Li-Hua Chen, You-Ming Li, Department of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
Lin Li
Chao-Hui Yu
Zhe Shen
Li-Hua Chen
You-Ming Li
National Natural Science Foundation of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the relationship between the gut-liver axis and nonalcoholic fatty liver disease (NAFLD), we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD.

methodsWe searched PubMed, Medline, Embase, Web of Science, the Cochrane Library and Chinese Biomedicine Database for all relevant randomized controlled trials on probiotics in patients with NAFLD/nonalcoholic steatohepatitis (NASH). A statistical analysis was performed using RevMan 5.0 software.

resultsFour randomized trials involving 134 NAFLD/NASH patients were included. The results showed that probiotic therapy significantly decreased alanine aminotransferase (ALT), aspartate transaminase (AST), total-cholesterol (T-chol), high density lipoprotein (HDL), tumor necrosis factor (TNF)-α and homeostasis model assessment of insulin resistance (HOMA-IR) [ALT: weighted mean difference (WMD) -23.71, 95%CI: -33.46--13.95, P < 0.00001; AST: WMD -19.77, 95%CI: -32.55--7.00, P = 0.002; T-chol: WMD -0.28, 95%CI: -0.55--0.01, P = 0.04; HDL: WMD -0.09, 95%CI: -0.16-0.01, P = 0.03; TNF-α: WMD -0.32, 95%CI: -0.48--0.17, P < 0.0001; HOMA-IR: WMD -0.46, 95%CI: -0.73--0.19, P = 0.0008]. However, the use of probiotics was not associated with changes in body mass index (BMI), glucose (GLU) and low density lipoprotein (LDL) (BMI: WMD 0.05, 95%CI: -0.18-0.29, P = 0.64; GLU: WMD 0.05, 95%CI: -0.25-0.35, P = 0.76; LDL: WMD -0.38, 95%CI: -0.78-0.02, P = 0.06).

conclusionProbiotic therapies can reduce liver aminotransferases, total-cholesterol, TNF-α and improve insulin resistance in NAFLD patients. Modulation of the gut microbiota represents a new treatment for NAFLD.

Indexed as

Chi-Square DistributionFatty LiverHumansInsulin ResistanceIntestinesLipid MetabolismLiverNon-alcoholic Fatty Liver DiseaseOdds RatioProbioticsTreatment OutcomeInsulin resistanceLiver functionMeta-analysisNonalcoholic fatty liver diseaseNonalcoholic steatohepatitisProbiotics

Identifiers

PMID24187469
PMCPMC3812493
OpenAlexW2151623669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.