ArticleWorld journal of gastroenterology2013
Clinical applications of next-generation sequencing in colorectal cancers.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The Utility of Lipidomic Analysis in Colorectal Cancer Diagnosis and Prognosis-A Systematic Review of Recent Literature.International journal of molecular sciences · 2024Pooled it
- Utilization of whole exome sequencing to identify hereditary mutations in Palestinian families with hereditary cancers.Frontiers in genetics · 2026Article
- Different types of reactions to E7386 among colorectal cancer patient-derived organoids and corresponding CAFs.Oncology letters · 2022Article
- Multigene Panel Sequencing Reveals Cancer-Specific and Common Somatic Mutations in Colorectal Cancer Patients: An Egyptian Experience.Current issues in molecular biology · 2022Article
- The Clinical Versatility of Next-Generation Sequencing in Colorectal Cancer.American journal of biomedical science & research · 2020Article
- A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma.Cancer management and research · 2020Article
- In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers.Analytical cellular pathology (Amsterdam) · 2019Article
- Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing.Oncotarget · 2018Article
- Oncogene c-Myc promotes epitranscriptome mOncotarget · 2018Article
- Molecular Landscape and Treatment Options for Patients with Metastatic Colorectal Cancer.Indian journal of surgical oncology · 2017Review
- Article
- Molecular predictive markers in tumors of the gastrointestinal tract.World journal of gastrointestinal oncology · 2016Review
- Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma.Oncotarget · 2015Article
- Personalized treatment for colorectal cancer: novel developments and putative therapeutic strategies.Langenbeck's archives of surgery · 2015Review
- Next-generation sequencing for genetic testing of familial colorectal cancer syndromes.Hereditary cancer in clinical practice · 2015Article
- Genomic era diagnosis and management of hereditary and sporadic colon cancer.World journal of clinical oncology · 2014Review
- Cancer in silico drug discovery: a systems biology tool for identifying candidate drugs to target specific molecular tumor subtypes.Molecular cancer therapeutics · 2014Article
- MAP: Mutation Arranger for Defining Phenotype-Related Single-Nucleotide Variant.Genomics & informatics · 2014Article
- How Can Next-Generation Sequencing (Genomics) Help Us in Treating Colorectal Cancer?Current colorectal cancer reports · 2014Article
- Genetic unraveling of colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like other solid tumors, colorectal cancer (CRC) is a genomic disorder in which various types of genomic alterations, such as point mutations, genomic rearrangements, gene fusions, or chromosomal copy number alterations, can contribute to the initiation and progression of the disease. The advent of a new DNA sequencing technology known as next-generation sequencing (NGS) has revolutionized the speed and throughput of cataloguing such cancer-related genomic alterations. Now the challenge is how to exploit this advanced technology to better understand the underlying molecular mechanism of colorectal carcinogenesis and to identify clinically relevant genetic biomarkers for diagnosis and personalized therapeutics. In this review, we will introduce NGS-based cancer genomics studies focusing on those of CRC, including a recent large-scale report from the Cancer Genome Atlas. We will mainly discuss how NGS-based exome-, whole genome- and methylome-sequencing have extended our understanding of colorectal carcinogenesis. We will also introduce the unique genomic features of CRC discovered by NGS technologies, such as the relationship with bacterial pathogens and the massive genomic rearrangements of chromothripsis. Finally, we will discuss the necessary steps prior to development of a clinical application of NGS-related findings for the advanced management of patients with CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.