Evidence map›Paper›PMID 24187440›Full record

ArticleJournal of micromechanics and microengineering : structures, devices, and systems2013

MEMS-based shear characterization of soft hydrated samples.

Gadryn C Higgs, Chelsey S Simmons, Yingning Gao, Andrew Fried, Sung-Jin Park, Cindy Chung, Beth L Pruitt

Abstract read
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In one paragraph

Article in Journal of micromechanics and microengineering : structures, devices, and systems, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. MEMS device for applying shear and tension to an epithelium combined with fluorescent live cell imaging.Journal of micromechanics and microengineering : structures, devices, and systems · 2020
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gadryn C Higgs *Department of Mechanical Engineering, Stanford University, Stanford, CA, USA 94305.
Chelsey S Simmons *Department of Mechanical Engineering, Stanford University, Stanford, CA, USA 94305.
Yingning GaoDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA 94305.
Andrew FriedDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA 94305.
Sung-Jin ParkDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA 94305.
Cindy ChungDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA 94305.
Beth L PruittDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA 94305.

Funding

Force Clamp Systems for Evaluation of MechanotransductionR01EB006745 · NIBIB · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B, PRUITT, BETH L · 2007 to 2014
$3.1M
Nanostructuring and Molecular Imaging of Engineered Cardiovascular TissuesR33HL089027 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2009 to 2011
$2.3M
NHLBI NIH HHS R33 HL089027NIBIB NIH HHS R01 EB006745
6 · The paper itself

Abstract

We have designed, fabricated, calibrated and tested actuators for shear characterization to assess microscale shear properties of soft substrates. Here we demonstrate characterization of dry silicone and hydrated polyethelyne glycol. Microscale tools, including atomic force microscopes and nanoindenters, often have limited functionality in hydrated environments. While electrostatic comb-drive actuators are particularly susceptible to moisture damage, through chemical vapor deposition of hexamethyldisiloxane, we increase the hydrophobicity of our electrostatic devices to a water contact angle 90 ± 3°. With this technique we determine the effective shear stiffness of both dry and hydrated samples for a range of soft substrates. Using computational and analytical models, we compare our empirically determined effective shear stiffness with existing characterization methods, rheology and nanoindentation, for samples with shear moduli ranging from 5-320 kPa. This work introduces a new approach for microscale assessment of synthetic materials that can be used on biological materials for basic and applied biomaterials research.

Identifiers

PMID24187440
PMCPMC3811110

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.