ArticleThe Journal of biological chemistry2013
Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 15 citations in OpenAlex.
- MFSD7c functions as a transporter of choline at the blood-brain barrier.Cell research · 2024Article
- Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels.The Journal of cell biology · 2021Article
- Article
- Ethanolamine ameliorates mitochondrial dysfunction in cardiolipin-deficient yeast cells.The Journal of biological chemistry · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Choline is a precursor for the synthesis of phosphatidylcholine through the CDP-choline pathway. Saccharomyces cerevisiae expresses a single high affinity choline transporter at the plasma membrane, encoded by the HNM1 gene. We show that exposing cells to increasing levels of choline results in two different regulatory mechanisms impacting Hnm1 activity. Initial exposure to choline results in a rapid decrease in Hnm1-mediated transport at the level of transporter activity, whereas chronic exposure results in Hnm1 degradation through an endocytic mechanism that depends on the ubiquitin ligase Rsp5 and the casein kinase 1 redundant pair Yck1/Yck2. We present details of how the choline transporter is a major regulator of phosphatidylcholine synthesis.
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Registered trials
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