CrossTalk proposal: Mechanical ventilation-induced diaphragm atrophy is primarily due to inactivity.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed.

1. Effects of elevated positive end-expiratory pressure on diaphragmatic blood flow and vascular resistance during mechanical ventilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2020
   Trial
2. Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation.American journal of physiology. Lung cellular and molecular physiology · 2014
   Trial
3. The effects of COVID-19 on respiratory muscle performance: making the case for respiratory muscle testing and training.European respiratory review : an official journal of the European Respiratory Society · 2022
   Review
4. Supplemental oxygen administration during mechanical ventilation reduces diaphragm blood flow and oxygen delivery.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
   Article
5. Optogenetic activation of the diaphragm.Scientific reports · 2022
   Article
6. The phrenic neuromuscular system.Handbook of clinical neurology · 2022
   Review
7. Transcriptome profiling of the diaphragm in a controlled mechanical ventilation model reveals key genes involved in ventilator-induced diaphragmatic dysfunction.BMC genomics · 2021
   Article
8. Risk of COVID-19 disease in the elderly population and physiotherapy.Physiotherapy · 2020
   Article
9. Maintenance of spontaneous breathing at an intensity of 60%-80% may effectively prevent mechanical ventilation-induced diaphragmatic dysfunction.PloS one · 2020
   Article
10. Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill.Intensive care medicine experimental · 2019
    Review
11. Structural differences in the diaphragm of patients following controlled vs assisted and spontaneous mechanical ventilation.Intensive care medicine · 2019
    Article
12. Ventilator-induced diaphragm dysfunction in critical illness.Experimental biology and medicine (Maywood, N.J.) · 2018
    Review
13. Attenuation of ventilation-induced diaphragm dysfunction through toll-like receptor 4 and nuclear factor-κB in a murine endotoxemia model.Laboratory investigation; a journal of technical methods and pathology · 2018
    Article
14. Anatomy and physiology of phrenic afferent neurons.Journal of neurophysiology · 2017
    Review
15. Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation.Scientific reports · 2017
    Article
16. Dysfunction of respiratory muscles in critically ill patients on the intensive care unit.Journal of cachexia, sarcopenia and muscle · 2016
    Review
17. Rebuttal from Gary C. Sieck and Carlos B. Mantilla.The Journal of physiology · 2013
    Article
18. Diaphragm pacing elicits respiratory plasticity in awake rodents after C2 hemisection.Respiratory physiology & neurobiology
    Article

Corrections and comments

• Commented on by
  Rebuttal from Gary C. Sieck and Carlos B. Mantilla.2013

Authors and funding

4 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as