Evidence map›Paper›PMID 24187042›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2013

Acoustic and photoacoustic molecular imaging of cancer.

Katheryne E Wilson, Tzu Yin Wang, Jürgen K Willmann

Erratum issuedOpen access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
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  19. Recent progress in photoacoustic molecular imaging.Current opinion in chemical biology · 2018
    Review
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katheryne E WilsonDepartment of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, Stanford, California.
Tzu Yin Wang
Jürgen K Willmann
Stanford University · US

Funding

Stanford Molecular Imaging Scholars - SMISR25CA118681 · NCI · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2006 to 2015
$5.0M
Quantification and monitoring inflammation in IBD with Molecular UltrasoundR01DK092509 · NIDDK · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2012 to 2016
$2.4M
Molecular Ultrasound for Early Breast Cancer DetectionR01CA155289 · NCI · STANFORD UNIVERSITY · PI WILLMANN, JUERGEN KARL · 2011 to 2015
$1.6M
Early Detection of Pancreatic Cancer with Targeted Contrast-enhanced UltrasoundR21CA139279 · NCI · STANFORD UNIVERSITY · PI WILLMANN, JUERGEN KARL · 2009 to 2010
$388k
NCI NIH HHS R01 CA155289NCI NIH HHS R01 CA155289-01A1NCI NIH HHS R21 CA139279NCI NIH HHS R25 CA118681NIDDK NIH HHS NIH R01DK092509-01A1NIDDK NIH HHS R01 DK092509
6 · The paper itself

Abstract

Ultrasound and combined optical and ultrasonic (photoacoustic) molecular imaging have shown great promise in the visualization and monitoring of cancer through imaging of vascular and extravascular molecular targets. Contrast-enhanced ultrasound with molecularly targeted microbubbles can detect early-stage cancer through the visualization of targets expressed on the angiogenic vasculature of tumors. Ultrasonic molecular imaging can be extended to the imaging of extravascular targets through use of nanoscale, phase-change droplets and photoacoustic imaging, which provides further molecular information on cancer given by the chemical composition of tissues and by targeted nanoparticles that can interact with extravascular tissues at the receptor level. A new generation of targeted contrast agents goes beyond merely increasing imaging signal at the site of target expression but shows activatable and differential contrast depending on their interactions with the tumor microenvironment. These innovations may further improve our ability to detect and characterize tumors. In this review, recent developments in acoustic and photoacoustic molecular imaging of cancer are discussed.

Indexed as

AcousticsAnimalsContrast MediaHumansMolecular ImagingNeoplasmsPhotoacoustic TechniquesContrast Mediacancermicrobubblemolecular imagingnanodropletnanoparticlephotoacoustic imagingultrasound

Identifiers

PMID24187042
PMCPMC4084699
OpenAlexW2118042202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.