ArticleAmerican journal of epidemiology2013
Neonatal bilirubin levels and childhood asthma in the US Collaborative Perinatal Project, 1959-1965.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Bilirubin metabolism in early life and respiratory health during preschool age: A combined analysis of two independent birth cohorts.Med (New York, N.Y.) · 2024Pooled it
- Link Between History of Neonatal Jaundice and Early Childhood Allergic Diseases in South Korea.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Unraveling the impact of neonatal jaundice on allergic diseases: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Systematic druggable genome-wide mendelian randomization identifies therapeutic targets for childhood asthma.Medicine · 2025Article
- Neonatal microbiome dysbiosis decoded by mNGS: from mechanistic insights to precision interventions.Frontiers in cellular and infection microbiology · 2025Review
- Study on fresh processing key technology and quality influence of Cut Ophiopogonis Radix based on multi-index evaluation.Open life sciences · 2023Article
- Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation.Mucosal immunology · 2022Article
- Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales.Metabolites · 2021Article
- Effects of Recombinant IL-35-BCG on Treg/Th17 Cell Imbalance and Inflammatory Response in Asthmatic Newborn Mice Induced by RSV.Inflammation · 2021Article
- Unconjugated bilirubin is associated with protection from early-life wheeze and childhood asthma.The Journal of allergy and clinical immunology · 2021Article
- Gut microbial alterations in neonatal jaundice pre- and post-treatment.Bioscience reports · 2021Article
- Asthma and hyperbilirubinemia: a new aspect to analyze?Postepy dermatologii i alergologii · 2019Article
- Association between neonatal serum bilirubin and childhood obesity in preterm infants.Pediatric research · 2019Article
- Phototherapy for neonatal hyperbilirubinemia and childhood eczema, rhinitis and wheeze.Pediatrics and neonatology · 2019Article
- Phototherapy is associated with the decrease in serum globulin levels in neonatal hyperbilirubinemia.Biomedical reports · 2019Article
- Meconium microbiome associates with the development of neonatal jaundice.Clinical and translational gastroenterology · 2018Article
- Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study.Pediatric research · 2015Article
- Article
- Re: "Neonatal bilirubin levels and childhood asthma in the US Collaborative Perinatal Project, 1959-1965".American journal of epidemiology · 2014Article
- Invited commentary: does neonatal hyperbilirubinemia cause asthma?American journal of epidemiology · 2013Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence shows that asthma originates in early life. Studies have found that phototherapy and/or neonatal jaundice may be associated with asthma. We investigated the association between neonatal bilirubin levels and childhood asthma without phototherapy intervention in the Collaborative Perinatal Project, a multicenter prospective cohort study conducted in the United States from 1959 to 1965. A total of 54,795 livebirths were included, and 40,063 children were followed up until 7 years of age or older. Total serum bilirubin (TSB) levels were examined at 48 hours postpartum in newborns with birthweights of 2,250 g or more. Information on asthma and other diseases through age 7 years was summarized and confirmed by a group of pediatricians and child neurologists. Among 28,807 term infants, the overall prevalence of asthma was 5.26%. Risks of asthma increased with both maximum TSB levels and TSB levels at 48 hours postpartum (P for trend < 0.01). Neonatal maximum TSB levels greater than 15 mg/dL were associated with a 61% increase in the risk of childhood asthma (odds ratio = 1.61, 95% confidence interval: 1.04, 2.08) after adjustment for confounders. In this prospective cohort study of infants born at a time when phototherapy was unavailable, neonatal hyperbilirubinemia was associated with an increased risk of childhood asthma.
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