ArticleJournal of lipid research2014
Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue.
Article in Journal of lipid research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Systematic Review and Meta-Analysis of the Relative Dose-Response Tests to Assess Vitamin A Status.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
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- Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine.Journal of lipid research · 2025Article
- Immunometabolic effects ofImmunometabolism (Cobham, Surrey) · 2024Review
- The Absorption, Storage, and Transport of Ocular Carotenoids and Retinoids.Annual review of vision science · 2024Review
- Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential.Frontiers in pharmacology · 2024Review
- Genetic tuning of β-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice.Human molecular genetics · 2023Article
- Retinoid metabolism: new insights.Journal of molecular endocrinology · 2022Review
- Genetic dissection in mice reveals a dynamic crosstalk between the delivery pathways of vitamin A.Journal of lipid research · 2022Article
- β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022Article
- Retinol Binding Protein 7 Promotes AdipogenesisFrontiers in cell and developmental biology · 2022Article
- Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions.Journal of lipid research · 2021Article
- Interplay between β-carotene and lipoprotein metabolism at the maternal-fetal barrier.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight.Science advances · 2020Article
- Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.Pharmacology & therapeutics · 2019Review
- Recent insights on the role and regulation of retinoic acid signaling during epicardial development.Genesis (New York, N.Y. : 2000) · 2019Review
- Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ.The Journal of biological chemistry · 2019Article
- Distribution and determinants of retinol in Norwegian adolescents, and its relation to bone mineral density: the Tromsø Study: Fit Futures.European journal of clinical nutrition · 2018Article
- Retinol-binding protein 4 regulates the biological functions and molecular mechanisms of JEG-3 cells.International journal of clinical and experimental pathology · 2018Article
- Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
Approximately 80-90% of all retinoids in the body are stored as retinyl esters (REs) in the liver. Adipose tissue also contributes significantly to RE storage. The present studies, employing genetic and nutritional interventions, explored factors that are responsible for regulating RE accumulation in the liver and adipose tissue and how these influence levels of retinoic acid (RA) and RA-responsive gene expression. Our data establish that acyl-CoA:retinol acyltransferase (ARAT) activity is not involved in RE synthesis in the liver, even when mice are nutritionally stressed by feeding a 25-fold excess retinol diet or upon ablation of cellular retinol-binding protein type I (CRBPI), which is proposed to limit retinol availability to ARATs. Unlike the liver, where lecithin:retinol acyltransferase (LRAT) is responsible for all RE synthesis, this is not true for adipose tissue where Lrat-deficient mice display significantly elevated RE concentrations. However, when CrbpI is also absent, RE levels resemble wild-type levels, suggesting a role for CrbpI in RE accumulation in adipose tissue. Although expression of several RA-responsive genes is elevated in Lrat-deficient liver, employing a sensitive liquid chromatography tandem mass spectrometry protocol and contrary to what has been assumed for many years, we did not detect elevated concentrations of all-trans-RA. The elevated RA-responsive gene expression was associated with elevated hepatic triglyceride levels and decreased expression of Pparδ and its downstream Pdk4 target, suggesting a role for RA in these processes in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.