ArticlePlanta1992
On the molecular mechanism of the circadian clock: The 64000-Mr protein of Chlamydomonas reinhardtii might be related to the biological clock.
Article in Planta, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 7 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Labelling of Chlamydomonas reinhardtii cells with [(35)S] methionine led to the detection of a 64-kDa polypeptide which is synthesized according to a circadian rhythm. The change in synthesis rate could be demonstrated to exist under constant dim-light conditions as well as in darkness. Maximum synthesis of the 64-kDa polypeptide occurred at about 10 h after onset of constant conditions, and the period length of its oscillation was about 29 h. The 64-kDa polypeptide was synthesized on 80S ribosomes as shown by experiments in which cycloheximide and chloramphenicol were supplied to the cultures. Peptide-microsequence analysis yielded an N-terminal sequence of 14 amino acids. No significant homology to any other known polypeptide could be demonstrated in searches of current databases. The possible role of the 64-kDa polypeptide and its relationship to the biological clock is discussed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.