ArticleJournal of materials science. Materials in medicine2014
Preparation and evaluation of novel nano-bioglass/gelatin conduit for peripheral nerve regeneration.
Article in Journal of materials science. Materials in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 70 citations in OpenAlex.
- Harnessing nanotechnology for stem-cell therapies: revolutionizing neurodegenerative disorder treatments - a state-of-the-art update.Frontiers in pharmacology · 2025Review
- Engineered bio-functional material-based nerve guide conduits for optic nerve regeneration: a view from the cellular perspective, challenges and the future outlook.Regenerative biomaterials · 2025Review
- Microstructure and Bioactivity of Ca- and Mg-Modified Silicon Oxycarbide-Based Amorphous Ceramics.Materials (Basel, Switzerland) · 2024Article
- Nanomaterials-incorporated hydrogels for 3D bioprinting technology.Nano convergence · 2023Review
- Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review.Journal of functional biomaterials · 2022Review
- Use of bioactive glass doped with magnesium or strontium for bone regeneration: A rabbit critical-size calvarial defects study.Dental research journal · 2022Article
- Bioactive Materials for Soft Tissue Repair.Frontiers in bioengineering and biotechnology · 2021Review
- Three dimensional printed bioglass/gelatin/alginate composite scaffolds with promoted mechanical strength, biomineralization, cell responses and osteogenesis.Journal of materials science. Materials in medicine · 2020Article
- Natural-Based Biomaterials for Peripheral Nerve Injury Repair.Frontiers in bioengineering and biotechnology · 2020Review
- Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering.Materials (Basel, Switzerland) · 2017Review
- Biodegradable Bisvinyl Sulfonemethyl-crosslinked Gelatin Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats.Scientific reports · 2017Article
- Polymeric scaffolds for three-dimensional culture of nerve cells: a model of peripheral nerve regeneration.MRS communications · 2017Article
- Synthesis and In Vitro Activity Assessment of Novel Silicon Oxycarbide-Based Bioactive Glasses.Materials (Basel, Switzerland) · 2016Article
- Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications.Materials (Basel, Switzerland) · 2016Review
- Nerve autografts and tissue-engineered materials for the repair of peripheral nerve injuries: a 5-year bibliometric analysis.Neural regeneration research · 2015Article
- Ultrasound imaging of chitosan nerve conduits that bridge sciatic nerve defects in rats.Neural regeneration research · 2014Article
- Article
- Hydrogel-based nanocomposites and mesenchymal stem cells: a promising synergistic strategy for neurodegenerative disorders therapy.TheScientificWorldJournal · 2013Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerves are exposed to physical injuries usually caused by trauma that may lead to a significant loss of sensory or motor functions and is considered as a serious health problem for societies today. This study was designed to develop a novel nano bioglass/gelatin conduit (BGGC) for the peripheral nerve regeneration. The bioglass nanoparticles were prepared by sol-gel technique and characterized using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction analysis. The interfacial bonding interaction between the nano-bioglass and gelatin in the developed conduits was assessed by FTIR. The surface morphology and pore size of the nanocomposite were investigated through scanning electron microscopy with the pore size of the conduits being 10-40 μm. Biocompatibility was assessed by MTT assay which indicated the BGGC to have good cytocompatibility. The guidance channel was examined and used to regenerate a 10 mm gap in the right sciatic nerve of a male Wistar rat. Twenty rats were randomly divided into two experimental groups, one with the BGGC and the other being normal rats. The gastrocnemius muscle contractility was also examined at one, two and three months post-surgery in all groups using electromyography (EMAP). Histological and functional evaluation and the results obtained from electromyography indicated that at three months, nerve regeneration of the BGGC group was statistically equivalent to the normal group (p > 0.05). Our result suggests that the BGGC can be a suitable candidate for peripheral nerve repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.