ArticleInternational journal of legal medicine2014
Evaluation of genetic parameters of 22 autosomal STR loci (PowerPlex® Fusion System) in a population sample from Northern Italy.
Article in International journal of legal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Phylogenetic analysis of the enigmatic Kalash population in Pakistan.Scientific reports · 2025Article
- Decreased accuracy of forensic DNA mixture analysis for groups with lower genetic diversity.iScience · 2024Article
- Comprehensive analyses for genetic diversities of 19 autosomal STRs in Chinese Kazak group and its phylogenetic relationships with other continental populations.Forensic sciences research · 2022Article
- Sequence variations, flanking region mutations, and allele frequency at 31 autosomal STRs in the central Indian population by next generation sequencing (NGS).Scientific reports · 2021Article
- Population genetic analyses and evaluation of 22 autosomal STRs in Indian populations.International journal of legal medicine · 2017Article
- [Polymorphism analysis of 20 autosomal short-tandem repeat loci in southern Chinese Han population].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2016Article
- Kinship analysis: assessment of related vs unrelated based on defined pedigrees.International journal of legal medicine · 2016Article
- Investigator HDplex markers: allele frequencies and mutational events in a North Italian population.International journal of legal medicine · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
The PowerPlex® Fusion System (Promega, Madison, WI) is a short tandem repeat (STR) multiplex that allows co-amplification of 22 autosomal STRs, including the CODIS core and the European Standard Set loci, plus amelogenin for gender determination and DYS391 male specific marker included in order to avoid errors in gender assignment when null Y-alleles or deletions of the Y-chromosome short arm involve the amelogenin locus. Allele frequencies and forensic efficiency parameters were estimated in a population sample of 303 unrelated healthy individuals living in Northern Italy. No significant deviations from Hardy-Weinberg expectations were observed after applying Bonferroni's correction for multiple testing. The combined power of discrimination was 0.999999999999 and the combined power of exclusion was 0.9999956. A rare 28 allele at locus D12S391 was observed, while one tri-allelic pattern at Penta E locus was detected. Population differentiation test revealed significant genetic diversity between our population sample and other European populations considered. The results showed that the PowerPlex® Fusion System is one of the most informative kit available in forensic genetics and may prove useful in both human identification and kinship analysis.
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