Evidence map›Paper›PMID 24185590›Full record

ArticleBone marrow transplantation2014

Similar outcomes between adolescent/young adults and children with AML following allogeneic hematopoietic cell transplantation.

M J Burke, N Gossai, Q Cao, M L Macmillan, E Warlick, M R Verneris

Abstract read
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In one paragraph

Article in Bone marrow transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

M J BurkeDivision of Pediatric Hematology-Oncology-BMT, Medical College of Wisconsin, Milwaukee, WI, USA.
N GossaiDepartment of Pediatrics, University of Minnesota Amplatz Children's Hospital, Minneapolis, MN, USA.
Q CaoBiostatistic Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
M L MacmillanDivision of Pediatric Blood and Marrow Transplantation, University of Minnesota Amplatz Children's Hospital, Minneapolis, MN, USA.
E WarlickDivision of Blood and Marrow transplantation, University of Minnesota, Minneapolis, MN, USA.
M R VernerisDivision of Pediatric Blood and Marrow Transplantation, University of Minnesota Amplatz Children's Hospital, Minneapolis, MN, USA.
University of Minnesota Children's Hospital · USUniversity of Minnesota · USMedical College of Wisconsin · US

Funding

NCI NIH HHS CA96028
6 · The paper itself

Abstract

We recently reported that adolescents and young adults (AYAs) with B-cell ALL receiving allogeneic hematopoietic cell transplantation (allo-HCT) have inferior survival compared with children, primarily because of greater TRM. We therefore hypothesized that in the setting of allo-HCT for AML, similar inferior outcomes would be observed in AYA patients as compared with children. We reviewed outcomes of 168 consecutive patients (ages 0-30 years) with AML undergoing allo-HCT at our institution. Of these, 60% (n=101) were <15 years of age and 40% (n=67) were AYAs (15-30 years of age). We identified no significant differences in 5-year overall survival (48% vs 50%, P=0.89), disease-free (47% vs 47%, P=0.89), relapse (24% vs 33%, P=0.30) or TRM (27% vs 16%, P=0.10) between the two groups. However, AYA patients had a greater incidence of grade II-IV acute (48% vs 31%, P=0.01) and chronic GVHD (22% vs 7%, P<0.01). Based on this analysis we identified no differences in survival, relapse or TRM between AYAs and children with AML receiving allo-HCT.

Indexed as

AdolescentAdultChildChild, PreschoolDisease-Free SurvivalFemaleHematopoietic Stem Cell TransplantationHumansInfantInfant, NewbornLeukemia, Myeloid, AcuteMaleTransplantation, AutologousTransplantation ConditioningTreatment OutcomeYoung Adult

Identifiers

PMID24185590
OpenAlexW1994740245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.