ArticleNature neuroscience2013
Regulation of interneuron excitability by gap junction coupling with principal cells.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 49 citations in OpenAlex.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Dynamic electrical synapses rewire brain networks for persistent oscillations and epileptogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Calcium-Sensitive Subthreshold Oscillations and Electrical Coupling in Principal Cells of Mouse Dorsal Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Functionally Distinct Circuits Are Linked by Heterocellular Electrical Synapses in the Thalamic Reticular Nucleus.eNeuro · 2024Article
- D-type K+ current rules the function of electrically coupled neurons in a species-specific fashion.The Journal of general physiology · 2023Article
- Connexin36 RNA Expression in the Cochlear Nucleus of the Echolocating Bat, Eptesicus fuscus.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Intersegmental coordination of the central pattern generator via interleaved electrical and chemical synapses in zebrafish spinal cord.Journal of computational neuroscience · 2023Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- On the Diverse Functions of Electrical Synapses.Frontiers in cellular neuroscience · 2022Review
- Structure and function of the gap junctional network of photoreceptive ganglion cells.Visual neuroscience · 2021Article
- Amacrine Cells Forming Gap Junctions With Intrinsically Photosensitive Retinal Ganglion Cells: ipRGC Types, Neuromodulator Contents, and Connexin Isoform.Investigative ophthalmology & visual science · 2021Article
- Brain Disorders and Chemical Pollutants: A Gap Junction Link?Biomolecules · 2020Review
- Article
- Intranasal Administration of PACAP Is an Efficient Delivery Route to Reduce Infarct Volume and Promote Functional Recovery After Transient and Permanent Middle Cerebral Artery Occlusion.Frontiers in endocrinology · 2020Article
- Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method.Journal of visualized experiments : JoVE · 2018Article
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- Connexins and pannexins: At the junction of neuro-glial homeostasis & disease.Journal of neuroscience research · 2018Review
- Electrical synapses convey orientation selectivity in the mouse retina.Nature communications · 2017Article
- A calcium-dependent pathway underlies activity-dependent plasticity of electrical synapses in the thalamic reticular nucleus.The Journal of physiology · 2017Article
- Synchrony and so much more: Diverse roles for electrical synapses in neural circuits.Developmental neurobiology · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Electrical coupling of inhibitory interneurons can synchronize activity across multiple neurons, thereby enhancing the reliability of inhibition onto principal cell targets. It is unclear whether downstream activity in principal cells controls the excitability of such inhibitory networks. Using paired patch-clamp recordings, we show that excitatory projection neurons (fusiform cells) and inhibitory stellate interneurons of the dorsal cochlear nucleus form an electrically coupled network through gap junctions containing connexin36 (Cxc36, also called Gjd2). Remarkably, stellate cells were more strongly coupled to fusiform cells than to other stellate cells. This heterologous coupling was functionally asymmetric, biasing electrical transmission from the principal cell to the interneuron. Optogenetically activated populations of fusiform cells reliably enhanced interneuron excitability and generated GABAergic inhibition onto the postsynaptic targets of stellate cells, whereas deep afterhyperpolarizations following fusiform cell spike trains potently inhibited stellate cells over several hundred milliseconds. Thus, the excitability of an interneuron network is bidirectionally controlled by distinct epochs of activity in principal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.