ArticleEnvironmental health perspectives2014
Exposure to brominated trihalomethanes in water during pregnancy and micronuclei frequency in maternal and cord blood lymphocytes.
Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
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7 citing papers in PubMed, 26 citations in OpenAlex.
- Human health risk estimation and predictive modeling of halogenated disinfection by- products (chloroform) in swimming pool waters: a case study of Dhanbad, Jharkhand, India.Journal of environmental health science & engineering · 2020Article
- Maternal swimming pool exposure during pregnancy in relation to birth outcomes and cord blood DNA methylation among private well users.Environment international · 2019Article
- Coupling external with internal exposure metrics of trihalomethanes in young females from Kuwait and Cyprus.Journal of exposure science & environmental epidemiology · 2018Article
- Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study.Environment international · 2018Article
- Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete).European journal of nutrition · 2018Article
- Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris).Environmental health perspectives · 2015Article
- Hydraulic fracturing: paving the way for a sustainable future?Journal of environmental and public health · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWater disinfection by-products have been associated with an increased cancer risk. Micronuclei (MN) frequency in lymphocytes is a marker of genomic damage and can predict adult cancer risk.
objectiveWe evaluated maternal exposure to drinking water brominated trihalomethanes (BTHM) in relation to MN frequency in maternal and cord blood lymphocytes.
methodsMN frequency was examined in 214 mothers and 223 newborns from the Rhea mother-child cohort in Crete, Greece, in 2007-2008. Residential BTHM water concentrations were estimated during pregnancy using tap water analyses and modeling. Questionnaires on water related habits were used to estimate BTHM exposure from all routes. Associations between BTHM and MN frequency were estimated using negative binomial regression.
resultsBTHM concentrations in residential tap water during pregnancy ranged from 0.06 to 7.1 μg/L. MN frequency in maternal binucleated lymphocytes was found to increase with BTHM concentrations in residential water for exposure during the first [rate ratio (RR) for 1 μg/L=1.05; 95% CI: 1.00, 1.11] and second trimesters (RR for 1 μg/L=1.03; 95% CI: 1.00, 1.06), and through all routes of BTHM exposure during the first trimester (RR for 1 μg/week=3.14; 95% CI: 1.16, 8.50).
conclusionsThese findings suggest that exposure to BTHM may increase the frequency of MN in maternal binucleated lymphocytes.
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