ReviewFrontiers in neuroendocrinology2014
Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes.
Review in Frontiers in neuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of war-related posttraumatic stress disorder in adolescents: a systematic review and meta-analysis.European journal of psychotraumatology · 2025Pooled it
- Social isolation at adolescence: a systematic review on behaviour related to cocaine, amphetamine and nicotine use in rats and mice.Psychopharmacology · 2021Pooled it
- Stressful life events during adolescence and risk for externalizing and internalizing psychopathology: a meta-analysis.European child & adolescent psychiatry · 2017Pooled it
- The effect of teaching puberty health concepts on the basis of a health belief model for improving perceived body image of female adolescents: a quasi-experimental study.BMC public health · 2020Trial
- Stress sensitization among severely neglected children and protection by social enrichment.Nature communications · 2019Trial
- Peripheral Inflammation In Adult ADHD: Sex Differences And Hematological Markers.The Psychiatric quarterly · 2026Article
- Structural equation modeling of the effect of childhood trauma on premenstrual syndrome: the mediating role of rumination in adolescent girls.Scientific reports · 2026Article
- Social withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability.Schizophrenia research · 2026Article
- Article
- Behavioral impact of adolescent social isolation stress: A multidimensional assessment in male NMRI mice.Learning & behavior · 2026Article
- Dimensional Anhedonia Rating Scale (DARS) Turkish Version: Examination of Psychometric Properties in Depressed and Ultra-High Risk/Psychotic Adolescents.The Psychiatric quarterly · 2026Article
- Determinants and outcomes of pubertal stress recalibration process: A scoping review.Biological psychology · 2026Article
- Prenatal Alcohol Exposure: Impact on Neuroimmune Function in the Stress Response and Pain.Advances in experimental medicine and biology · 2026Review
- Article
- Exercise-induced anandamide-CB1R signaling and prefrontal-amygdala stress circuits in adolescent depression: a critical hypothesis-driven narrative review.Frontiers in psychiatry · 2026Review
- Sex differences and the roles of sex steroids in energy intake regulation and high-fat diet preference during free-choice feeding in young adult rats.Frontiers in endocrinology · 2026Article
- A Network Analysis of the Interrelationships Between Depression, Anxiety, Insomnia and Non-Suicidal Self-Injury in Middle School Students.Psychology research and behavior management · 2026Article
- Rifaximin improves anxiety- and depression-like behaviors in rats by regulating NPY in the colon and mPFC.Scientific reports · 2025Article
- A Brief, Affordable, Broad-Access Transdiagnostic Intervention (Project RE-THINK) for Adolescents: Quasi-Experimental Study.JMIR mental health · 2025Article
- Adolescent stress exposure induces persistent, sex-specific cognitive deficits.Neurobiology of learning and memory · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Puberty and adolescence are major life transitions during which an individual's physiology and behavior changes from that of a juvenile to that of an adult. Here we review studies documenting the effects of stressors during pubertal and adolescent development on the adult brain and behavior. The experience of complex or compound stressors during puberty/adolescence generally increases stress reactivity, increases anxiety and depression, and decreases cognitive performance in adulthood. These behavioral changes correlate with decreased hippocampal volumes and alterations in neural plasticity. Moreover, stressful experiences during puberty disrupt behavioral responses to gonadal hormones both in sexual performance and on cognition and emotionality. These behavioral changes correlate with altered estrogen receptor densities in some estrogen-concentrating brain areas, suggesting a remodeling of the brain's response to hormones. A hypothesis is presented that activation of the immune system results in chronic neuroinflammation that may mediate the alterations of hormone-modulated behaviors in adulthood.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.