ReviewAmerican journal of obstetrics and gynecology2014
Pregnancy, parturition and preeclampsia in women of African ancestry.
Review in American journal of obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05091827 (Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in Utero), which is not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of the Cardiovascular Risk Profile of Infants Exposed to Pre-eclampsia in Utero
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Long-term cardiovascular outcome in women with preeclampsia in Korea: a large population-based cohort study and meta-analysis.Scientific reports · 2024Pooled it
- Pooled it
- Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis.BMC pregnancy and childbirth · 2019Pooled it
- Complement factor B activation in patients with preeclampsia.Journal of reproductive immunology · 2015Trial
- Placental and umbilical cord morphometry in preeclampsia and their association with neonatal outcomes: a preliminary study in Ghana.BMC pregnancy and childbirth · 2026Article
- Abnormal renal function three months after delivery among pre-eclampsia survivors in Sub-Saharan Africa: a prospective cohort study in Uganda.BMC pregnancy and childbirth · 2026Article
- Challenges and Prospects in Managing Hypertensive Disorders of Pregnancy in Sub-Saharan Africa: A Narrative Review.International journal of women's health · 2026Review
- Review
- Risk factors associated with progression from pre-eclampsia to eclampsia: A prospective cohort study and population-wide data analysis.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Postpartum Cardiovascular Health in African Women Following Pre-Eclampsia: A Prospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Variations in emergency care for severe pre-eclampsia in Uganda: a national evaluation study.AJOG global reports · 2025Article
- Global, Regional, and National Burden and Trends of Maternal Hypertensive Disorders from 1990 to 2021: A Population-Based Study.International journal of women's health · 2025Article
- Incidence of pre-eclampsia and its associated factors among pregnant women attending antenatal clinic at the 37 Military Hospital in Ghana.BMJ nutrition, prevention & health · 2025Article
- Administration patterns of magnesium sulphate for women with preeclampsia and immediate newborn outcomes in Kawempe National Referral Hospital-Uganda: a cohort study.BMC pregnancy and childbirth · 2024Observational
- Implementation challenges in preeclampsia care: perspectives from health care professionals in urban Uganda.AJOG global reports · 2024Article
- No association of a Vascular endothelial growth factor A (VEGFA) gene polymorphism with pre-eclampsia among pregnant women in Uganda.BMC genomics · 2023Article
- Maternal hypertensive mother's knowledge, attitudes and misconceptions on hypertension in pregnancy: A multi-center qualitative study in Ghana.PLOS global public health · 2023Article
- The central role of natural killer cells in preeclampsia.Frontiers in immunology · 2023Review
- Fetal High-Risk APOL1 Genotype Increases Risk for Small for Gestational Age in Term Infants Affected by Preeclampsia.Neonatology · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Maternal and associated neonatal mortality rates in sub-Saharan Africa remain unacceptably high. In Mulago Hospital (Kampala, Uganda), 2 major causes of maternal death are preeclampsia and obstructed labor and their complications, conditions occurring at the extremes of the birthweight spectrum, a situation encapsulated as the obstetric dilemma. We have questioned whether the prevalence of these disorders occurs more frequently in indigenous African women and those with African ancestry elsewhere in the world by reviewing available literature. We conclude that these women are at greater risk of preeclampsia than other racial groups. At least part of this susceptibility seems independent of socioeconomic status and likely is due to biological or genetic factors. Evidence for a genetic contribution to preeclampsia is discussed. We go on to propose that the obstetric dilemma in humans is responsible for this situation and discuss how parturition and birthweight are subject to stabilizing selection. Other data we present also suggest that there are particularly strong evolutionary selective pressures operating during pregnancy and delivery in Africans. There is much greater genetic diversity and less linkage disequilibrium in Africa, and the genes responsible for regulating birthweight and placentation may therefore be easier to define than in non-African cohorts. Inclusion of African women into research on preeclampsia is an essential component in tackling this major disparity of maternal health.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.