Evidence map›Paper›PMID 24183940›Full record

ReviewTrends in endocrinology and metabolism: TEM2014

Effects of bioactive lipids and lipoproteins on bone.

Yin Tintut, Linda L Demer

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. A Beginner's Guide for Using Bone in Marine Mammal Research.Integrative and comparative biology · 2026
    Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yin TintutDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: ytintut@mednet.ucla.edu.
Linda L DemerDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Physiology, University of California, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · US

Funding

Regulation of PTH-induced Osteoanabolism by Inflammatory LipidsR01DK081346 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TINTUT, YIN · 2009 to 2013
$1.8M
Role of Inhibitory SMADs in Calcific Aortic Valve DiseaseR01HL114709 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2012 to 2015
$1.5M
Role of Lymphatic Clearance in Lipid-Induced Calcific Vasculopathy and Bone LossR21HL109628 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2011 to 2012
$424k
NHLBI NIH HHS HL109628NHLBI NIH HHS HL114709NHLBI NIH HHS R01 HL114709NHLBI NIH HHS R21 HL109628NIDDK NIH HHS DK081346NIDDK NIH HHS R01 DK081346
6 · The paper itself

Abstract

Although epidemiological studies from the past two decades show a link between atherosclerotic vascular disease and bone loss, that is independent of age, the mechanism is still unclear. This review focuses on evidence that suggests a role for atherogenic lipids and lipoproteins in the pathogenesis of bone loss, including direct effects of these bioactive lipids/lipoproteins on bone cells, inhibiting osteoblastic differentiation and promoting osteoclastic differentiation. It also addresses recent evidence that suggests that bioactive lipids blunt the effects of bone anabolic agents such as teriparatide and bone morphogenetic proteins. Systemic and intracellular oxidant stress and inflammation are implicated in mediating the effects of bioactive lipids/lipoproteins.

Indexed as

Anabolic AgentsAnimalsAtherosclerosisBone and BonesBone DensityCell DifferentiationCholesterol, HDLFemaleHumansHyperlipidemiasInflammationLipidsLipoproteinsMiceOsteoblastsOsteoclastsAnabolic AgentsCholesterol, HDLLipidsLipoproteinsParathyroid Hormone

Identifiers

PMID24183940
PMCPMC3946677
OpenAlexW2009092353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.