Evidence map›Paper›PMID 24183931›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2014

New tides: using zebrafish to study renal regeneration.

Kristen K McCampbell, Rebecca A Wingert

Open access · greenAbstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Regeneration in fish, with special focus on killifishes.Fish physiology and biochemistry · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Principles of Zebrafish Nephron Segment Development.Journal of developmental biology · 2023
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Zebrafish as a model for kidney function and disease.Pediatric nephrology (Berlin, Germany) · 2019
    Review
  15. Nephron repair: powered by anaerobic energy metabolism.Annals of translational medicine · 2019
    Article
  16. eLife · 2018
    Article
  17. Article
  18. Review
  19. Article
  20. Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury.Journal of visualized experiments : JoVE · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kristen K McCampbellDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Ind.
Rebecca A WingertDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Ind. Electronic address: rwingert@nd.edu.
University of Notre Dame · US

Funding

Identification of Kidney Regeneration Mechanisms Using the ZebrafishDP2OD008470 · OD · UNIVERSITY OF NOTRE DAME · PI WINGERT, REBECCA ANN · 2011 to 2011
$2.3M
Generation of novel models of kidney defects using the zebrafishR01DK100237 · NIDDK · UNIVERSITY OF NOTRE DAME · PI WINGERT, REBECCA ANN · 2013 to 2017
$1.8M
Genetic Analysis of Pathways Controlling Nephron Segmentation Using the ZebrafishK01DK083512 · NIDDK · UNIVERSITY OF NOTRE DAME · PI WINGERT, REBECCA ANN · 2009 to 2013
$644k
NIDDK NIH HHS K01 DK083512NIDDK NIH HHS R01 DK100237NIH HHS DP2 OD008470
6 · The paper itself

Abstract

Over the past several decades, the zebrafish has become one of the major vertebrate model organisms used in biomedical research. In this arena, the zebrafish has emerged as an applicable system for the study of kidney diseases and renal regeneration. The relevance of the zebrafish model for nephrology research has been increasingly appreciated as the understanding of zebrafish kidney structure, ontogeny, and the response to damage has steadily expanded. Recent studies have documented the amazing regenerative characteristics of the zebrafish kidney, which include the ability to replace epithelial populations after acute injury and to grow new renal functional units, termed nephrons. Here we discuss how nephron composition is conserved between zebrafish and mammals, and highlight how recent findings from zebrafish studies utilizing transgenic technologies and chemical genetics can complement traditional murine approaches in the effort to dissect how the kidney responds to acute damage and identify therapeutics that enhance human renal regeneration.

Indexed as

Models, AnimalRegenerationAnimalsKidneyZebrafish

Identifiers

PMID24183931
PMCPMC3946610
OpenAlexW2069331466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.