ReviewSeizure2014
Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG).
Review in Seizure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Midazolam infusions for therapeutic management of pediatric refractory status epilepticus: a systematic review.Frontiers in pediatrics · 2025Pooled it
- [Efficacy and safety of levetiracetam versus phenytoin as second-line drugs for the treatment of children with convulsive status epilepticus: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Pooled it
- Time to treatment in pediatric patients with repeated episodes of status epilepticus.BMC neurology · 2025Observational
- Treating seizures faster: The Quality Improvement in Time to Treat Status Epilepticus (QuITT-SE) multicenter randomized stepped wedge clinical trial protocol.Contemporary clinical trials · 2025Article
- Preventing Long-Term Brain Damage by Nerve Agent-Induced Status Epilepticus in Rat Models Applicable to Infants: Significant Neuroprotection by Tezampanel Combined with Caramiphen but Not by Midazolam Treatment.The Journal of pharmacology and experimental therapeutics · 2024Article
- Clinical, radiological and electrophysiological predictors for drug-resistant epilepsy.The Egyptian journal of neurology, psychiatry and neurosurgery · 2023Article
- Article
- Article
- Time Elapsed from Onset of Pediatric Convulsive Status Epilepticus to Antiepileptic Administration-An Experience of Single Institute.Indian journal of pediatrics · 2022Observational
- Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus.Epilepsia · 2021Observational
- Factors associated with long-term outcomes in pediatric refractory status epilepticus.Epilepsia · 2021Article
- Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort).Epilepsia · 2021Article
- The etiology and risk factors of convulsive status epilepticus in pediatric patients of tertiary center in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2021Article
- Indications for Inpatient Magnetoencephalography in Children - An Institution's Experience.Frontiers in human neuroscience · 2021Article
- Article
- Article
- Knowledge and attitudes among preschools staff in Shanghai, China, regarding epilepsy.BMC pediatrics · 2020Article
- Association of guideline publication and delays to treatment in pediatric status epilepticus.Neurology · 2020Article
- Clinical application of target temperature management in children with acute encephalopathy-A practical review.Biomedical journal · 2020Review
- Refractory and Super-refractory Status Epilepticus.Indian pediatrics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
Abstract
purposeStatus epilepticus (SE) is a life-threatening condition that can be refractory to initial treatment. Randomized controlled studies to guide treatment choices, especially beyond first-line drugs, are not available. This report summarizes the evidence that guides the management of refractory convulsive SE (RCSE) in children, defines gaps in our clinical knowledge and describes the development and works of the 'pediatric Status Epilepticus Research Group' (pSERG).
methodsA literature review was performed to evaluate current gaps in the pediatric SE and RCSE literature. In person and online meetings helped to develop and expand the pSERG network.
resultsThe care of pediatric RCSE is largely based on extrapolations of limited evidence derived from adult literature and supplemented with case reports and case series in children. No comparative effectiveness trials have been performed in the pediatric population. Gaps in knowledge include risk factors for SE, biomarkers of SE and RCSE, second- and third-line treatment options, and long-term outcome.
conclusionThe care of children with RCSE is based on limited evidence. In order to address these knowledge gaps, the multicenter pSERG was established to facilitate prospective collection, analysis, and sharing of de-identified data and biological specimens from children with RCSE. These data will allow identification of treatment strategies associated with better outcomes and delineate evidence-based interventions to improve the care of children with SE.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.