ReviewTrends in cardiovascular medicine2014
Lymphatic vessel abnormalities arising from disorders of Ras signal transduction.
Review in Trends in cardiovascular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Review
- Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition.JCI insight · 2023Article
- Imaging peripheral lymphatic dysfunction in chronic conditions.Frontiers in physiology · 2023Review
- Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Osteopathy in Complex Lymphatic Anomalies.International journal of molecular sciences · 2022Review
- Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.JCI insight · 2022Article
- The RASopathies: from pathogenetics to therapeutics.Disease models & mechanisms · 2022Review
- RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice.Development (Cambridge, England) · 2020Article
- SPRED proteins and their roles in signal transduction, development, and malignancy.Genes & development · 2020Review
- Ras Pathways on Prox1 and Lymphangiogenesis: Insights for Therapeutics.Frontiers in cardiovascular medicine · 2020Review
- RASA1-dependent cellular export of collagen IV controls blood and lymphatic vascular development.The Journal of clinical investigation · 2019Article
- RASA1 regulates the function of lymphatic vessel valves in mice.The Journal of clinical investigation · 2017Article
- Lymphatic pumping: mechanics, mechanisms and malfunction.The Journal of physiology · 2016Review
- Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation.The Journal of clinical investigation · 2016Article
- Pediatric lymphatic malformations: evolving understanding and therapeutic options.Pediatric surgery international · 2016Review
- Lymphatic fate specification: an ERK-controlled transcriptional program.Microvascular research · 2014Review
- Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A number of genetic diseases in man have been described in which abnormalities in the development and function of the lymphatic vascular (LV) system are prominent features. The genes that are mutated in these diseases are varied and include genes that encode lymphatic endothelial cell (LEC) growth factor receptors and their ligands and transcription factors that control LEC fate and function. In addition, an increasing number of genes have been identified that encode components of the Ras signal transduction pathway that conveys signals from cell surface receptors to regulate cell growth, proliferation, and differentiation. Gene targeting studies performed in mice have confirmed that the LV system is particularly susceptible to perturbations in the Ras pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.