ArticleThe Journal of allergy and clinical immunology2014
Dissection of the IgE and T-cell recognition of the major group 5 grass pollen allergen Phl p 5.
Article in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Mechanisms, safety and efficacy of a B cell epitope-based vaccine for immunotherapy of grass pollen allergy.EBioMedicine · 2016Trial
- B-cell epitope prediction for developing allergy vaccines and their companion immunodiagnostics.Frontiers in immunology · 2025Article
- Multiplex basophil activation tests for allergy diagnosis: present and future applications.Frontiers in allergy · 2024Review
- IgE Epitopes of the House Dust Mite Allergen Der p 7 Are Mainly Discontinuous and Conformational.Frontiers in immunology · 2021Article
- Fusion proteins consisting of Bet v 1 and Phl p 5 form IgE-reactive aggregates with reduced allergenic activity.Scientific reports · 2019Article
- Molecular patterns in the isotype-specific antibody responses to the major cedar aeroallergen Jun a 1.Molecular immunology · 2018Article
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- Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity.The Journal of allergy and clinical immunology · 2017Article
- Clustering of conformational IgE epitopes on the major dog allergen Can f 1.Scientific reports · 2017Article
- Recombinant allergy vaccines based on allergen-derived B cell epitopes.Immunology letters · 2017Review
- Immunotherapy With the PreS-based Grass Pollen Allergy Vaccine BM32 Induces Antibody Responses Protecting Against Hepatitis B Infection.EBioMedicine · 2016Article
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- Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses.Particle and fibre toxicology · 2016Article
- Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy.The Journal of allergy and clinical immunology · 2015Article
- Multiple independent IgE epitopes on the highly allergenic grass pollen allergen Phl p 5.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Grass-specific CD4(+) T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Molecular biomarkers for grass pollen immunotherapy.World journal of methodology · 2014Review
- Allergen Peptides, Recombinant Allergens and Hypoallergens for Allergen-Specific Immunotherapy.Current treatment options in allergy · 2014Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe major timothy grass pollen allergen Phl p 5 belongs to the most potent allergens involved in hay fever and asthma.
objectiveThis study characterized immune-dominant IgE- and T-cell-recognition sites of Phl p 5.
methodsSeven peptides, P1 to P7 with a length of 31 to 38 amino acids that spanned the Phl p 5 sequence, were synthesized, characterized by circular dichroism spectroscopy, and tested for IgE reactivity, basophil activation, and T-cell reactivity. Carrier-bound peptides were studied for their ability to induce IgG antibodies in rabbits which recognize Phl p 5 or cross-reactive allergens from different grass species. Peptide-specific antibodies were tested for the capability to inhibit IgE reactivity to Phl p 5 and allergen-induced basophil activation of patients with allergy.
resultsThe peptides exhibited no secondary structure and showed no IgE reactivity or relevant allergenic activity, indicating that Phl p 5 IgE epitopes are conformational. Except for P3, peptide-specific IgG antibodies blocked IgE binding to Phl p 5 of patients with allergy and cross-reacted with temperate grasses. IgE inhibition experiments and molecular modeling identified several clustered conformational IgE epitopes on the N- as well as C-terminal domain of Phl p 5. P4, which stimulated the strongest T-cell and cytokine responses in patients, was not part of the major IgE-reactive regions.
conclusionOur study shows an interesting dissociation of the major IgE- and T-cell-reactive domains in Phl p 5 which provides a basis for the development of novel forms of immunotherapy that selectively target IgE or T-cell responses.
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