ReviewBest practice & research. Clinical gastroenterology2013
Cost-effectiveness of screening and treating Helicobacter pylori for gastric cancer prevention.
Review in Best practice & research. Clinical gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long Term Effects of H.Pylori Eradication on Microbiome and Adverse Events
EU4Health Project Eurohelican: A Single-center Prospective Feasibility Study of the Proposed Test-and-treat Preventive Screening Program in Younger Slovenian Participants Aged 30-34 Years With or Without Helicobacter Pylori Infection
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Social determinants of health andFrontiers in public health · 2025Pooled it
- Cost-Effectiveness of Screening Helicobacter pylori for Gastric Cancer Prevention: a Systematic Review.Journal of gastrointestinal cancer · 2022Pooled it
- Prevalence ofFrontiers in oncology · 2022Pooled it
- Prevalence of Helicobacter pylori infection worldwide: a systematic review of studies with national coverage.Digestive diseases and sciences · 2014Pooled it
- Multicentric randomised study ofBMJ open · 2017Trial
- eCROPS-CA: a systematic approach toward effective and sustainable cancer prevention in rural China.BMC cancer · 2015Trial
- From screening to surveillance: integrated prevention ofThe Lancet regional health. Western Pacific · 2026Review
- Optimal upper gastrointestinal surveillance strategies for gastric, small bowel and pancreatic cancer detection in Lynch syndrome.Familial cancer · 2026Review
- Spatiotemporal analysis of gastric cancer incidence in Iran from 2014 to 2018: a geospatial epidemiological study.BMC public health · 2025Article
- A summary of the National Cancer Institute Think Tank on Advancing Gastric Cancer Prevention.Journal of the National Cancer Institute · 2025Article
- Characteristics Associated With Spontaneous Helicobacter pylori Clearance After Subtotal Gastrectomy in Patients With Gastric Cancer.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- Comparative Analysis of Diagnostic Techniques for Helicobacter pylori Infection: Insights for Effective Therapy.Journal of cellular and molecular medicine · 2025Article
- Spatial Clusters of Cancer Mortality in Brazil: A Machine Learning Modeling Approach.International journal of public health · 2023Article
- Cost-Effectiveness Analysis of the Helicobacter Pylori Screening Programme in an Asymptomatic Population in China.International journal of environmental research and public health · 2022Article
- The role of the occupational physician in controlling gastric cancer attributable toPreventive medicine reports · 2021Review
- Economic and health impacts of introducing Helicobacter pylori eradication strategy into national gastric cancer policy in Japan: A cost-effectiveness analysis.Helicobacter · 2021Article
- Review
- Cost-effectiveness modelling of use of urea breath test for the management ofBMJ open gastroenterology · 2021Article
- Gastric cancer: lessons learned from high-incidence geographic regions.Journal of gastrointestinal oncology · 2021Review
- Current status ofWorld journal of gastroenterology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Gastric cancer is the second leading cause of cancer-related death worldwide. A meta-analysis of seven randomized controlled trials concluded that Helicobacter pylori eradication reduces gastric cancer incidence by 35%. Current consensus is that H. pylori screening and treatment is cost-effective only in high-risk populations. This paper provides an up-to-date overview of the evidence for cost-effectiveness of H. pylori screening and treatment in different population settings and risk levels for H. pylori infection. Ten unique cost-effectiveness or cost-utility analyses were identified. All found that screening for H. pylori to prevent gastric cancer in the general population costs less than $50,000 per LYG. This finding was robust for differences in H. pylori prevalence, gender and ethnicity. Based on limited evidence, re-treatment (for treatment failure), repeated screening, limiting screening and treatment to those with the CagA phenotype, or universal treatment, does not appear to be cost-effective. However, most included studies failed to consider both the broader benefits as well as the adverse effects of widespread use of antibiotics for H. pylori.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.