ArticleBMC genomics2013
Antennal transcriptome profiles of anopheline mosquitoes reveal human host olfactory specialization in Anopheles gambiae.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 123 citations in OpenAlex.
- Relative proportion and contrasting host preference of Culex pipiens biotypes across Europe.Parasites & vectors · 2026Article
- Sensitivity to cuticular hydrocarbons across the odorant receptor family in the Indian jumping ant,Frontiers in insect science · 2026Article
- Genetic variation in olfactory pathways associated with host-seeking behavior in natural populations of Anopheles minimus, a primary malaria vector in western Thailand.Parasites & vectors · 2025Article
- Differential expression of antennal chemosensory genes related to host preference of Culex pipiens biotypes.Parasites & vectors · 2025Article
- Genomics of urban adaptation and exaptation in mosquitoes and consequences for vectorial capacity.Current opinion in insect science · 2025Review
- Increased heterozygosity and balancing selection in isofemale generations of Anopheles stephensi under laboratory conditions.BMC genomics · 2025Article
- Molecular evolution of gustatory receptors in the Anopheles gambiae complex.BMC ecology and evolution · 2025Article
- Gene drives: an alternative approach to malaria control?Gene therapy · 2025Review
- Genetic and behavioral differences between above and below ground Culex pipiens bioforms.Heredity · 2024Article
- Unravelling the genome of the brackish water malaria vector Anopheles aquasalis.Scientific reports · 2023Article
- Hybridization Chain Reaction RNA Whole-Mount Fluorescence In situ Hybridization of Chemosensory Genes in Mosquito Olfactory Appendages.Journal of visualized experiments : JoVE · 2023Article
- Antennal morphology and sensilla ultrastructure of the malaria vectors, Anopheles maculatus and An. sawadwongporni (Diptera: Culicidae).Arthropod structure & development · 2023Article
- Article
- Identification and expression profile analysis of chemosensory genes in pine needle gall midge,Frontiers in physiology · 2023Article
- Article
- Genome of the hoverfly Eupeodes corollae provides insights into the evolution of predation and pollination in insects.BMC biology · 2022Article
- Screening for odorant receptor genes expressed in Aedes aegypti involved in host-seeking, blood-feeding and oviposition behaviors.Parasites & vectors · 2022Article
- Human attractive cues and mosquito host-seeking behavior.Trends in parasitology · 2022Review
- Insights Into Chemosensory Proteins From Non-Model Insects: Advances and Perspectives in the Context of Pest Management.Frontiers in physiology · 2022Review
- Odorant Binding Proteins (OBPs) and Odorant Receptors (ORs) of Anopheles stephensi: Identification and comparative insights.PloS one · 2022Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
backgroundTwo sibling members of the Anopheles gambiae species complex display notable differences in female blood meal preferences. An. gambiae s.s. has a well-documented preference for feeding upon human hosts, whereas An. quadriannulatus feeds on vertebrate/mammalian hosts, with only opportunistic feeding upon humans. Because mosquito host-seeking behaviors are largely driven by the sensory modality of olfaction, we hypothesized that hallmarks of these divergent host seeking phenotypes will be in evidence within the transcriptome profiles of the antennae, the mosquito's principal chemosensory appendage.
resultsTo test this hypothesis, we have sequenced antennal mRNA of non-bloodfed females from each species and observed a number of distinct quantitative and qualitative differences in their chemosensory gene repertoires. In both species, these gene families show higher rates of sequence polymorphisms than the overall rates in their respective transcriptomes, with potentially important divergences between the two species. Moreover, quantitative differences in odorant receptor transcript abundances have been used to model potential distinctions in volatile odor receptivity between the two sibling species of anophelines.
conclusionThis analysis suggests that the anthropophagic behavior of An. gambiae s.s. reflects the differential distribution of olfactory receptors in the antenna, likely resulting from a co-option and refinement of molecular components common to both species. This study improves our understanding of the molecular evolution of chemoreceptors in closely related anophelines and suggests possible mechanisms that underlie the behavioral distinctions in host seeking that, in part, account for the differential vectorial capacity of these mosquitoes.
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