ArticleThe Plant journal : for cell and molecular biology2014
Inter-regulation of the unfolded protein response and auxin signaling.
Article in The Plant journal : for cell and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Dynamic regulation of proteostasis underlies thermopriming-mediated acquired thermotolerance in Arabidopsis.Plant communications · 2026Article
- The core morning clock component CCA1 enhances UPR target gene expression to facilitate ER stress recovery.Plant communications · 2025Article
- Identification and characterization of DICER-LIKE genes and their roles in Marchantia polymorpha development and salt stress response.The Plant journal : for cell and molecular biology · 2025Article
- Endoplasmic reticulum stress controls PIN-LIKES abundance and thereby growth adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth.Plants (Basel, Switzerland) · 2022Review
- The UPR regulator IRE1 promotes balanced organ development by restricting TOR-dependent control of cellular differentiation in Arabidopsis.The Plant journal : for cell and molecular biology · 2022Article
- Endoplasmic Reticulum Stress and Unfolded Protein Response Signaling in Plants.International journal of molecular sciences · 2022Review
- Unfolded protein response in balancing plant growth and stress tolerance.Frontiers in plant science · 2022Review
- ER-Localized PIN Carriers: Regulators of Intracellular Auxin Homeostasis.Plants (Basel, Switzerland) · 2020Review
- Effects of Jasmonic Acid in ER Stress and Unfolded Protein Response in Tomato Plants.Biomolecules · 2020Article
- Pathogenic Bacteria Target Plant Plasmodesmata to Colonize and Invade Surrounding Tissues.The Plant cell · 2020Article
- Salt stress induces endoplasmic reticulum stress-responsive genes in a grapevine rootstock.PloS one · 2020Article
- A Functional Unfolded Protein Response Is Required for Normal Vegetative Development.Plant physiology · 2019Article
- Transport from the endoplasmic reticulum to the Golgi in plants: Where are we now?Seminars in cell & developmental biology · 2018Review
- Research Progress in the Pathogenesis of Alzheimer's Disease.Chinese medical journal · 2018Review
- Salicylic acid-independent role of NPR1 is required for protection from proteotoxic stress in the plant endoplasmic reticulum.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Maintaining the factory: the roles of the unfolded protein response in cellular homeostasis in plants.The Plant journal : for cell and molecular biology · 2017Article
- CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses.The Plant journal : for cell and molecular biology · 2017Article
- Inositol-requiring enzyme 1 affects meristematic division in roots under moderate salt stress in Arabidopsis.Plant biotechnology (Tokyo, Japan) · 2017Article
- The Unfolded Protein Response Supports Plant Development and Defense as well as Responses to Abiotic Stress.Frontiers in plant science · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The unfolded protein response (UPR) is a signaling network triggered by overload of protein-folding demand in the endoplasmic reticulum (ER), a condition termed ER stress. The UPR is critical for growth and development; nonetheless, connections between the UPR and other cellular regulatory processes remain largely unknown. Here, we identify a link between the UPR and the phytohormone auxin, a master regulator of plant physiology. We show that ER stress triggers down-regulation of auxin receptors and transporters in Arabidopsis thaliana. We also demonstrate that an Arabidopsis mutant of a conserved ER stress sensor IRE1 exhibits defects in the auxin response and levels. These data not only support that the plant IRE1 is required for auxin homeostasis, they also reveal a species-specific feature of IRE1 in multicellular eukaryotes. Furthermore, by establishing that UPR activation is reduced in mutants of ER-localized auxin transporters, including PIN5, we define a long-neglected biological significance of ER-based auxin regulation. We further examine the functional relationship of IRE1 and PIN5 by showing that an ire1 pin5 triple mutant enhances defects of UPR activation and auxin homeostasis in ire1 or pin5. Our results imply that the plant UPR has evolved a hormone-dependent strategy for coordinating ER function with physiological processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.