ArticleActa paediatrica (Oslo, Norway : 1992)2014
Neurophysiological measures of nociceptive brain activity in the newborn infant--the next steps.
Article in Acta paediatrica (Oslo, Norway : 1992), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Impact of skin-to-skin contact on acute procedural pain in newborns: a systematic review and meta-analysis.Jornal de pediatriaPooled it
- Impact of breast milk on cortical pain response in newborns during the heel prick procedure: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale, near-infrared spectroscopy, and ultrasonography: a randomized trial.World journal of pediatrics : WJP · 2023Trial
- Birth experience in newborn infants is associated with changes in nociceptive sensitivity.Scientific reports · 2019Trial
- Effects of hydrotherapy and hammock positioning on pain reduction in preterm neonates.Jornal de pediatriaTrial
- Different Patterns of Cortical Electrical Activity by Tactile, Acoustic and Visual Stimuli in Infants: An EEG Exploratory Study.Diagnostics (Basel, Switzerland) · 2025Article
- A comparison of the effect of procedural pain on cerebral oxygen saturation between late preterm and term infants.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect.PloS one · 2023Article
- Effects of white noise on procedural pain-related cortical response and pain score in neonates: A randomized controlled trial.International journal of nursing sciences · 2022Article
- Use of glucose for pain management in premature neonates: a systematic review and meta-analysis protocol.BMJ open · 2021Article
- Can Event-Related Potentials Evoked by Heel Lance Assess Pain Processing in Neonates? A Systematic Review.Children (Basel, Switzerland) · 2021Review
- Neonatal Pain: Perceptions and Current Practice.Critical care nursing clinics of North America · 2018Review
- Review
- Multi-modal pain assessment: are near-infrared spectroscopy, skin conductance, salivary cortisol, physiologic parameters, and Neonatal Facial Coding System interrelated during venepuncture in healthy, term neonates?Journal of pain research · 2018Article
- Correlation of changes in hemodynamic response as measured by cerebral optical spectrometry with subjective pain ratings in volunteers and patients: a prospective cohort study.Journal of pain research · 2018Article
- Simultaneous functional near-infrared spectroscopy and electroencephalography for monitoring of human brain activity and oxygenation: a review.Neurophotonics · 2017Review
- Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation.Magnetic resonance in medicine · 2017Article
- Nociceptive brain activity as a measure of analgesic efficacy in infants.Science translational medicine · 2017Article
- Growth of Thalamocortical Fibers to the Somatosensory Cortex in the Human Fetal Brain.Frontiers in neuroscience · 2017Article
- The relationship between nociceptive brain activity, spinal reflex withdrawal and behaviour in newborn infants.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledInfants within neonatal intensive care units can receive multiple medically essential painful procedures per day. How they respond to these events, how best to alleviate the negative effects, and the long-term consequences for the infant are all significant questions that have yet to be fully answered. In recent years, several studies have examined cortical responses to noxious stimuli in the neonate through the use of near-infrared spectroscopy (NIRS) and electroencephalography (EEG). These investigations dispel any notion that the newborn infant does not process noxious stimuli at a cortical level and open the way for future research. In this Viewpoint Article, we review these studies and discuss key clinical challenges which may be elucidated with the use of these techniques.
conclusionSimultaneously measuring the changes that are evoked in behaviour, physiology and the cortex following noxious events will provide the best approach to understanding the neonate's experience of pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.