ArticleBMC genomics2013
Life based on phosphite: a genome-guided analysis of Desulfotignum phosphitoxidans.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Lithosyntrophy: Obligate syntrophy in a phosphite-oxidizing, methanogenic culture.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Widespread promiscuous alkaline phosphatases underscore ancient microbial phosphite utilization.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The functional mechanisms of phosphite and its applications in crop plants.Frontiers in plant science · 2025Review
- Review
- AMP-dependent phosphite dehydrogenase, a phosphorylating enzyme in dissimilatory phosphite oxidation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Obligate autotrophy at the thermodynamic limit of life in a new acetogenic bacterium.Frontiers in microbiology · 2023Article
- On the potential roles of phosphorus in the early evolution of energy metabolism.Frontiers in microbiology · 2023Review
- The diversity and evolution of microbial dissimilatory phosphite oxidation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Phosphorus redox reactions as pinch hitters in microbial metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Metagenomics-guided analysis of microbial chemolithoautotrophic phosphite oxidation yields evidence of a seventh natural COProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Stratified Bacterial Diversity along Physico-chemical Gradients in High-Altitude Modern Stromatolites.Frontiers in microbiology · 2017Article
- Freshwater bacteria release methane as a byproduct of phosphorus acquisition.Applied and environmental microbiology · 2016Article
- A novel genetic engineering platform for the effective management of biological contaminants for the production of microalgae.Plant biotechnology journal · 2016Article
- Genome sequence of Shinella sp. strain DD12, isolated from homogenized guts of starved Daphnia magna.Standards in genomic sciences · 2016Article
- Differentiating phosphate-dependent and phosphate-independent systemic phosphate-starvation response networks in Arabidopsis thaliana through the application of phosphite.Journal of experimental botany · 2015Article
- Genome sequence of Pedobacter glucosidilyticus DD6b, isolated from zooplankton Daphnia magna.Standards in genomic sciences · 2015Article
- Draft Genome Sequence of Serratia sp. Strain DD3, Isolated from the Guts of Daphnia magna.Genome announcements · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Delta-Proteobacterium Desulfotignum phosphitoxidans is a type strain of the genus Desulfotignum, which comprises to date only three species together with D. balticum and D. toluenicum. D. phosphitoxidans oxidizes phosphite to phosphate as its only source of electrons, with either sulfate or CO2 as electron acceptor to gain its metabolic energy, which is of exclusive interest. Sequencing of the genome of this bacterium was undertaken to elucidate the genomic basis of this so far unique type of energy metabolism.
resultsThe genome contains 4,998,761 base pairs and 4646 genes of which 3609 were assigned to a function, and 1037 are without function prediction. Metabolic reconstruction revealed that most biosynthetic pathways of Gram negative, autotrophic sulfate reducers were present. Autotrophic CO2 assimilation proceeds through the Wood-Ljungdahl pathway. Additionally, we have found and confirmed the ability of the strain to couple phosphite oxidation to dissimilatory nitrate reduction to ammonia, which in itself is a new type of energy metabolism. Surprisingly, only two pathways for uptake, assimilation and utilization of inorganic and organic phosphonates were found in the genome. The unique for D. phosphitoxidans Ptx-Ptd cluster is involved in inorganic phosphite oxidation and an atypical C-P lyase-coding cluster (Phn) is involved in utilization of organophosphonates.
conclusionsWe present the whole genome sequence of the first bacterium able to gain metabolic energy via phosphite oxidation. The data obtained provide initial information on the composition and architecture of the phosphite-utilizing and energy-transducing systems needed to live with phosphite as an unusual electron donor.
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