Evidence map›Paper›PMID 24180225›Full record

ArticleVirology journal2013

Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis.

Simon Hood, Jane L Mitchell, Meera Sethi, Neil M Almond, Keith L Cutler, Nicola J Rose

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Simon Hood
Jane L Mitchell
Meera Sethi
Neil M Almond
Keith L Cutler
Nicola J RoseDivision of Virology, National Institute for Biological Standards and Control, Blanche Lane, Medicines and Healthcare products Regulatory Agency, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. nicola.rose@nibsc.org.
National Institute for Biological Standards and Control · GB

Funding

Medical Research Council G0601201Medical Research Council G9025730
6 · The paper itself

Abstract

backgroundFoamy viruses are non-pathogenic in vivo and naturally infect all species of non-human primates (NHP). Simian foamy viruses (SFV) are highly prevalent in both free ranging and captive NHP but few longitudinal studies have been performed to assess the prevalence and biodistribution of SFV within captive NHP.

methodLTR and pol gene along with Gag antibody detection were undertaken to identify infection in a cohort of over 80 captive macaques.

resultsThe prevalence of SFV was between 64% and 94% in different groups. Access to 23 dam-infant pairs allowed us to reveal horizontal transfer as the dominant route of SFV transmission in our cohort. Further, analysis of SFV from a range of tissues and blood revealed that macaques as young as six months old can be infected and that proviral biodistribution increases with age.

conclusionsThese are the first data of this type for a captive cohort of cynomolgus macaques.

Indexed as

Disease Transmission, InfectiousAnimalsAntibodies, ViralCluster AnalysisFemaleGene Products, gagGene Products, polMacaca fascicularisMaleMolecular EpidemiologyMolecular Sequence DataPhylogenyPrevalenceRetroviridae InfectionsRNA, ViralSequence Analysis, DNAAntibodies, ViralGene Products, gagGene Products, polRNA, Viral

Identifiers

PMID24180225
PMCPMC4228416
OpenAlexW2134490074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.