ArticleBMC genomics2013
Proteomic and metabolomic profiles of larval hemolymph associated with diapause in the cotton bollworm, Helicoverpa armigera.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 79 citations in OpenAlex.
- The clock gene cycle synchronizes circadian metabolic oscillations uniquely in reproductively active Culex pipiens females.npj metabolic health and disease · 2026Article
- The transcriptome reveals the potential mechanism of 20E terminating diapause in cotton bollworm, Helicoverpa armigera.BMC genomics · 2025Article
- Article
- Transcription profiling reveals tissue-specific metabolic pathways in the fat body and ovary of the diapausing mosquito Culex pipiens.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2024Article
- Molecular Correlates of Diapause inInsects · 2024Article
- Consuming royal jelly alters several phenotypes associated with overwintering dormancy in mosquitoes.Frontiers in insect science · 2024Article
- Mmp-induced fat body cell dissociation promotes pupal development and moderately averts pupal diapause by activating lipid metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Rapid brain development and reduced neuromodulator titres correlate with host shifts inRoyal Society open science · 2022Article
- Metabolomics Reveals Changes in Metabolite Profiles among Pre-Diapause, Diapause and Post-Diapause Larvae ofInsects · 2022Article
- Diapause vs. reproductive programs: transcriptional phenotypes in a keystone copepod.Communications biology · 2021Article
- The impact of persistent colonization byThe Journal of experimental biology · 2020Article
- Optimizing cultivation ofComputational and structural biotechnology journal · 2020Article
- Mating precedes selective immune priming which is maintained throughout bumblebee queen diapause.BMC genomics · 2019Article
- Comparative Transcriptomic Analysis Reveals Molecular Profiles of Central Nervous System in Maternal Diapause Induction ofG3 (Bethesda, Md.) · 2019Article
- Metabolomics reveals novel insight on dormancy of aquatic invertebrate encysted embryos.Scientific reports · 2019Article
- Understanding the regulation of overwintering diapause molecular mechanisms in Culex pipiens pallens through comparative proteomics.Scientific reports · 2019Article
- Diapause-associated changes in the lipid and metabolite profiles of the Asian tiger mosquito,The Journal of experimental biology · 2018Article
- Article
- FoxO Transcription Factor Regulate Hormone Mediated Signaling on Nymphal Diapause.Frontiers in physiology · 2018Article
- Dormancy in Embryos: Insight from Hydrated Encysted Embryos of an Aquatic Invertebrate.Molecular & cellular proteomics : MCP · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiapause is programmed developmental arrest coupled with the depression of metabolic activity and the enhancement of stress resistance. Pupal diapause is induced by environmental signals and is prepared during the prediapause phase. In the cotton bollworm, Helicoverpa armigera, the prediapause phase, which contains two sub-phases, diapause induction and preparation, occurs in the larval stage. Here, we performed parallel proteomic and metabolomic analyses on H. armigera larval hemolymph during the prediapause phase.
resultsBy two-dimensional electrophoresis, 37 proteins were shown to be differentially expressed in diapause-destined larvae. Of these proteins, 28 were successfully identified by MALDI-TOF/TOF mass spectrometry. Moreover, a total of 22 altered metabolites were found in diapause-destined larval hemolymph by GC-MS analysis, and the levels of 17 metabolites were elevated and 5 were decreased.
conclusionsThe proteins and metabolites with significantly altered levels play different roles in diapause-destined larvae, including diapause induction, metabolic storage, immune response, stress tolerance, and others. Because hemolymph circulates through the whole body of an insect, these differences found in diapause-destined larvae most likely correspond to upstream endocrine signals and would further influence other organ/tissue activities to determine the insect's fact: diapause or development.
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