ArticleNeuroImage. Clinical2013
Subcortical volumes are reduced in short-term and long-term abstinent alcoholics but not those with a comorbid stimulant disorder.
Article in NeuroImage. Clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Problematic alcohol use and reduced hippocampal volume: a meta-analytic review.Psychological medicine · 2017Pooled it
- Testing the consequences of alcohol, cannabis, and nicotine use on hippocampal volume: a quasi-experimental cotwin control analysis of young adult twins.Psychological medicine · 2023Article
- Caudate gray matter volumes and risk of relapse in Type A alcohol-dependent patients: A 7-year MRI follow-up study.Frontiers in psychiatry · 2023Article
- Shapes of subcortical structures in adolescents with and without familial history of substance use disorder.Human brain mapping · 2022Article
- Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis.Psychiatry research. Neuroimaging · 2021Article
- Memory impairment in alcohol use disorder is associated with regional frontal brain volumes.Drug and alcohol dependence · 2021Article
- Cognitive Dysfunction, Brain Volumes, and Traumatic Brain Injury in Homeless Persons.Neurotrauma reports · 2021Article
- Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder.PloS one · 2020Article
- Volumetric Reductions of Subcortical Structures and Their Localizations in Alcohol-Dependent Patients.Frontiers in neurology · 2019Article
- Testing associations between cannabis use and subcortical volumes in two large population-based samples.Addiction (Abingdon, England) · 2018Article
- Cortical thickness and subcortical brain volumes in professional rugby league players.NeuroImage. Clinical · 2018Article
- Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety.Journal of autism and developmental disorders · 2017Article
- Decreased subcortical volumes in alcohol dependent individuals: effect of polysubstance use disorder.Addiction biology · 2017Article
- Resting state synchrony in long-term abstinent alcoholics: Effects of a current major depressive disorder diagnosis.Alcohol (Fayetteville, N.Y.) · 2017Article
- Wine Flavonoids in Health and Disease Prevention.Molecules (Basel, Switzerland) · 2017Review
- Structural Neuroimaging in Polysubstance Users.Current opinion in behavioral sciences · 2017Article
- Thinking after Drinking: Impaired Hippocampal-Dependent Cognition in Human Alcoholics and Animal Models of Alcohol Dependence.Frontiers in psychiatry · 2016Review
- Endophenotypes for Alcohol Use Disorder: An Update on the Field.Current addiction reports · 2015Article
- Family history density of alcoholism relates to left nucleus accumbens volume in adolescent girls.Journal of studies on alcohol and drugs · 2015Article
- Conflict anticipation in alcohol dependence - A model-based fMRI study of stop signal task.NeuroImage. Clinical · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic alcohol abuse affects brain structure and function. We examined subcortical structure volumes in 77 short (6-15 week) and 90 long (multi-year) term abstinent alcoholics, along with 74 controls. We used a 3T Siemens MPRAGE sequence for image acquisition and FSL FIRST software for measuring subcortical volumes. When examining alcoholics without a comorbid stimulant disorder we found reduced hippocampal, pallidum and thalamus volumes in short term abstinence compared to a non-substance abusing control sample with numerically smaller yet still significant reductions compared to controls in long term abstinence. When examining alcoholics with a comorbid stimulant disorder, no difference from controls was found for any subcortical volume. Alcoholics with a stimulant disorder had significantly larger subcortical volumes than alcoholics without a stimulant disorder. This study replicates past research showing that chronic alcohol abuse is associated with lower subcortical volumes in short-term abstinent chronic alcoholics and extends this finding, although with smaller effects to long-term abstinent samples. The absence of this effect in the presence of a comorbid stimulant disorder suggests either a protective effect of stimulant abuse/dependence or that the measurements reflect the aggregate of alcohol dependence associated atrophy and stimulant abuse associated inflammation. Associations with function suggest the second of these two alternatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.