ArticleNeuroImage. Clinical2013
Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study.
Article in NeuroImage. Clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Pain-Related Fear Modulates Attentional Bias for Threat Processing in Chronic Pain: An ERP Study.Journal of pain research · 2026Article
- The Impact of Ageing on Episodic Memory Retrieval: How Valence Influences Neural Functional Connectivity.NeuroSci · 2024Article
- Change in Endogenous Pain Modulation Depending on Emotional States in Healthy Subjects: A Randomized Controlled Trial.Pain and therapy · 2024Article
- Investigating the brain functional abnormalities underlying pain hypervigilance in chronic neck and shoulder pain: a resting-state fMRI study.Neuroradiology · 2024Article
- Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study.Frontiers in human neuroscience · 2020Article
- Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder.Neuropsychiatric disease and treatment · 2020Article
- Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders.Journal of psychiatric research · 2018Article
- Persistent Valence Representations by Ensembles of Anterior Cingulate Cortex Neurons.Frontiers in systems neuroscience · 2018Article
- Functional Alterations of Postcentral Gyrus Modulated by Angry Facial Expressions during Intraoral Tactile Stimuli in Patients with Burning Mouth Syndrome: A Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2017Article
- A-MUPS score to differentiate patients with somatic symptom disorder from those with medical disease for complaints of non-acute pain.Journal of pain research · 2017Article
- Altered resting-state intra- and inter- network functional connectivity in patients with persistent somatoform pain disorder.PloS one · 2017Article
- Development of neural basis for chinese orthographic neighborhood size effect.Human brain mapping · 2016Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is a multidimensional phenomenon. Patients with somatoform pain disorder suffer from long-lasting pain, with the pathology being closely associated with cognitive-emotional components. Differences between these patients and controls in cerebral responses to pain stimuli have been reported. However, to our knowledge, no studies of somatoform pain disorder have evaluated altered pain-related brain activation as modulated by emotional dysregulation. We examined the distinct neural mechanism that is engaged in response to two different pain intensities in a sad emotional condition, performing functional magnetic resonance imaging (fMRI) on a group of 11 somatoform pain patients and an age-matched control group. Our results showed that the ratio for low-pain intensity ratings between the sad and neutral conditions in patients was higher than in controls. They also showed significant increased activation in the anterior/posterior insula in the low pain sadness condition. Furthermore, there was specific functional connectivity between the anterior insula and the parahippocampus in patients during presentation of low-pain stimuli in the sad context. These findings suggest that a negative emotional context such as sadness contributes to dysfunctional pain processing in somatoform pain disorder. Greater sensitivity to low levels of pain in an emotional context of sadness might be an important aspect of the psychopathology of somatoform pain disorder.
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