Evidence map›Paper›PMID 24179773›Full record

ArticleNeuroImage. Clinical2013

A comprehensive approach to the segmentation of multichannel three-dimensional MR brain images in multiple sclerosis.

Sushmita Datta, Ponnada A Narayana

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Deep learning segmentation of gadolinium-enhancing lesions in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021
    Article
  5. Article
  6. Article
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  10. Dual-Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018
    Article
  11. GRAPE: a graphical pipeline environment for image analysis in adaptive magnetic resonance imaging.International journal of computer assisted radiology and surgery · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sushmita DattaDepartment of Diagnostic and Interventional Imaging, The University of Texas Medical School at Houston, Houston, TX 77030, USA.
Ponnada A Narayana

Funding

MR Image Analysis in MS: Identification of a SurrogateR01EB002095 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI NARAYANA, PONNADA A · 2003 to 2011
$5.2M
Lesion Activity and Atrophy in Multiple Sclerosis: Analysis of Multi-center MRIR01NS078244 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI NARAYANA, PONNADA A · 2012 to 2016
$1.6M
MRS: NEUROLOGICAL DVMT &DISORDERS: LEARNING, READING, COGNITIVE, APHASIA, DYSLES10RR019186 · NCRR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI NARAYANA, PONNADA A · 2004 to 2004
$500k
NCRR NIH HHS S10 RR019186NIBIB NIH HHS R01 EB002095NINDS NIH HHS R01 NS078244
6 · The paper itself

Abstract

Accurate classification and quantification of brain tissues is important for monitoring disease progression, measurement of atrophy, and correlating magnetic resonance (MR) measures with clinical disability. Classification of MR brain images in the presence of lesions, such as multiple sclerosis (MS), is particularly challenging. Images obtained with lower resolution often suffer from partial volume averaging leading to false classifications. While partial volume averaging can be reduced by acquiring volumetric images at high resolution, image segmentation and quantification can be technically challenging. In this study, we integrated the brain anatomical knowledge with non-parametric and parametric statistical classifiers for automatically classifying tissues and lesions on high resolution multichannel three-dimensional images acquired on 60 MS brains. The results of automatic lesion segmentation were reviewed by the expert. The agreement between results obtained by the automated analysis and the expert was excellent as assessed by the quantitative metrics, low absolute volume difference percent (36.18 ± 34.90), low average symmetric surface distance (1.64 mm ± 1.30 mm), high true positive rate (84.75 ± 12.69), and low false positive rate (34.10 ± 16.00). The segmented results were also in close agreement with the corrected results as assessed by Bland-Altman and regression analyses. Finally, our lesion segmentation was validated using the MS lesion segmentation grand challenge dataset (MICCAI 2008).

Indexed as

BrainDeformationMultichannel MRIMultiple sclerosisSegmentation

Identifiers

PMID24179773
PMCPMC3777770
OpenAlexW1970736935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.