ArticleNeuroImage. Clinical2012
Thalamic medial dorsal nucleus atrophy in medial temporal lobe epilepsy: A VBM meta-analysis.
Article in NeuroImage. Clinical, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 7 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 7 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Imaging insights into temporal lobe epilepsy: an AES-SDM meta-analysis and retrospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Multimodal Abnormalities of Brain Structure and Function in Major Depressive Disorder: A Meta-Analysis of Neuroimaging Studies.The American journal of psychiatry · 2020Pooled it
- Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis.Clinical radiology · 2019Pooled it
- Structural and Functional Neural Targets of Addiction Treatment in Adolescents and Young Adults: A Systematic Review and Meta-Analysis.Journal of child and adolescent psychopharmacology · 2019Pooled it
- Structural brain correlates of interpersonal violence: Systematic review and voxel-based meta-analysis of neuroimaging studies.Psychiatry research. Neuroimaging · 2017Pooled it
- Patterns of gray matter atrophy in atypical parkinsonism syndromes: a VBM meta-analysis.Brain and behavior · 2015Pooled it
- Meta-analysis in human neuroimaging: computational modeling of large-scale databases.Annual review of neuroscience · 2014Pooled it
- Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy.Epilepsia · 2026Article
- Morphometric Similarity Loss and Gray Matter Atrophy Align with Neurotransmitter and Mitochondrial Maps in Drug-Resistant Epilepsy.Neuropsychiatric disease and treatment · 2026Article
- Structural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis.Brain organoid & systems neuroscience journal · 2025Article
- Thirty years of SPM-BrainMap synergy: making and mining coordinate-based literature.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Voxel-based and surface-based cortical morphometric MRI applications for identifying the epileptogenic zone: A narrative review.Epilepsia open · 2025Review
- Subcortical Gray Matter Volume Abnormalities in Temporal Lobe Epilepsy with Hippocampal Atrophy.Clinical medicine & research · 2024Observational
- Subcortical Alterations in Newly Diagnosed Epilepsy and Associated Changes in Brain Connectivity and Cognition.Human brain mapping · 2024Review
- Structural brain characteristics of epilepsy patients with comorbid migraine without aura.Scientific reports · 2024Article
- Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference.Brain : a journal of neurology · 2023Article
- Multi-scale structural alterations of the thalamus and basal ganglia in focal epilepsy using 7T MRI.Human brain mapping · 2023Article
- Automated subfield volumetric analysis of amygdala, hippocampus, and thalamic nuclei in mesial temporal lobe epilepsy.World neurosurgery: X · 2023Article
- Brain structural connectivity sub typing in unilateral temporal lobe epilepsy.Brain imaging and behavior · 2022Article
- Brain structural differences in temporal lobe and frontal lobe epilepsy patients: A voxel-based morphometry and vertex-based surface analysis.The neuroradiology journal · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
purposeMedial temporal lobe epilepsy (MTLE) is associated with MTLE network pathology within and beyond the hippocampus. The purpose of this meta-analysis was to identify consistent MTLE structural change to guide subsequent targeted analyses of these areas.
methodsWe performed an anatomic likelihood estimation (ALE) meta-analysis of 22 whole-brain voxel-based morphometry experiments from 11 published studies. We grouped these experiments in three ways. We then constructed a meta-analytic connectivity model (MACM) for regions of consistent MTLE structural change as reported by the ALE analysis. KEY
findingsALE reported spatially consistent structural change across VBM studies only in the epileptogenic hippocampus and the bilateral thalamus; within the thalamus, the medial dorsal nucleus of the thalamus (MDN thalamus) represented the greatest convergence (P < 0.05 corrected for multiple comparisons). The subsequent MACM for the hippocampus and ipsilateral MDN thalamus demonstrated that the hippocampus and ipsilateral MDN thalamus functionally co-activate and are nodes within the same network, suggesting that MDN thalamic damage could result from MTLE network excitotoxicity. SIGNIFICANCE: Notwithstanding our large sample of studies, these findings are more restrictive than previous reports and demonstrate the utility of our inclusion filters and of recently modified meta-analytic methods in approximating clinical relevance. Thalamic pathology is commonly observed in animal and human studies, suggesting it could be a clinically useful indicator. Thalamus-specific research as a clinical marker awaits further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.