ArticleOncology letters2013
Clinical significance of the induction of macrophage differentiation by the costimulatory molecule B7-H3 in human non-small cell lung cancer.
Article in Oncology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Global trends in tumor-associated neutrophil research: a bibliometric and visual analysis.Frontiers in immunology · 2025Pooled it
- From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer.Frontiers in immunology · 2024Review
- B7-H3 chimeric antigen receptor-modified T cell shows potential for targeted treatment of acute myeloid leukaemia.European journal of medical research · 2023Article
- High expression of cluster of differentiation 276 indicates poor prognosis in glioma.Clinical Medicine Insights. Oncology · 2021Article
- Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer.Frontiers in cell and developmental biology · 2021Article
- Silencing of CD276 suppresses lung cancer progression by regulating integrin signaling.Journal of thoracic disease · 2020Article
- The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy.Frontiers in oncology · 2020Review
- The expressions and significance of B7-H3 and CTLA-4 in the clinical stages of non-small-cell lung cancer.International journal of clinical and experimental pathology · 2019Article
- Prognostic Significance of CD276 in Non-small Cell Lung Cancer.Open medicine (Warsaw, Poland) · 2019Article
- Soluble immune checkpoints in cancer: production, function and biological significance.Journal for immunotherapy of cancer · 2018Review
- Involvement of soluble B7-H3 in combination with the serum inflammatory cytokines interleukin-17, -8 and -6 in the diagnosis of hepatocellular carcinoma.Oncology letters · 2017Article
- Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation.Cancer immunology research · 2017Article
- Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma.OncoTargets and therapy · 2017Article
- B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment.Mediators of inflammation · 2016Review
- Differential expression of 2IgB7-H3 and 4IgB7-H3 in cancer cell lines and glioma tissues.Oncology letters · 2015Article
- Inhibitory receptors as targets for cancer immunotherapy.European journal of immunology · 2015Review
- B7-H3 in combination with regulatory T cell is associated with tumor progression in primary human non-small cell lung cancer.International journal of clinical and experimental pathology · 2015Article
- B7-H3 expression in breast cancer and upregulation of VEGF through gene silence.OncoTargets and therapy · 2014Article
- MicroRNA-199a Inhibits Cell Proliferation, Migration, and Invasion and Activates AKT/mTOR Signaling Pathway by Targeting B7-H3 in Cervical Cancer.Technology in cancer research & treatmentArticle
Corrections and comments
- Retraction · 2014-04-08Error in Data · Unreliable Data · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B7-H3, a member of the B7 family of molecules, is expressed in certain types of human cancer and is important in tumor development and progression. Although several studies have reported that the expression of B7-H3 is correlated with poor outcomes in patients with cancer, its exact role in cancer remains unknown. In the present study, the expression levels of B7-H3 in the pathological specimens of 105 patients treated for non-small cell lung cancer (NSCLC) were examined by immunohistochemistry. A high expression level of B7-H3 was observed in 46.9% of the 105 NSCLC tissue specimens. These patients demonstrated a more advanced tumor grade and a shorter survival time. In addition, we also examined the levels of tumor-associated macrophages (TAMs) in NSCLC tissues and observed that the levels were positively correlated with the expression of B7-H3, and that higher levels of macrophages were associated with lower levels of infiltrating T cells and a shorter survival time. These results demonstrated that TAMs are important in the evasion of tumor immune surveillance in NSCLC. Furthermore, through knockdown of B7-H3 by RNA interference, we observed that soluble B7-H3 was capable of inducing macrophages to express higher levels of macrophage mannose receptor (MMR) and lower levels of human leukocyte antigen (HLA)-DR, as well as higher levels of interleukin-10 (IL-10) and lower levels of IL-1β
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.