ArticleThe Plant cell2013
ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 131 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
131 citing papers in PubMed, 1 synthesis or guideline pooled it, 311 citations in OpenAlex.
- Primary nitrate responses mediated by calcium signalling and diverse protein phosphorylation.Journal of experimental botany · 2020Pooled it
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- Molecular Mechanisms of Oil and Saponin Accumulation and the Regulation of Carbohydrate Metabolism inPlants (Basel, Switzerland) · 2026Article
- Genome-Wide Analysis ofPlants (Basel, Switzerland) · 2026Article
- Molecular characterization of SnRK2 gene family in Capsicum chinense and functional validation of CcSnRK2.5 under drought stress.Plant cell reports · 2026Article
- Resource allocation to pea plant nodules impacted by nitrogen fixation potential of infecting rhizobia.The ISME journal · 2026Article
- An evolutionary conserved CBL1-CIPK6 complex of oil persimmon involved in responses to ABA, salt and drought stress.BMC plant biology · 2025Article
- Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Genome-Wide Identification and Hormone-Induced Expression Analysis of the Anthocyanidin Reductase Gene Family in Sainfoin (International journal of molecular sciences · 2025Article
- Genome-wide analysis of the SnRK gene family in Caragana Korshinskii and their expression profiling under drought and nitrogen deposition.BMC genomics · 2025Article
- SoybeanPlants (Basel, Switzerland) · 2025Article
- Never-germinating Arabidopsis seeds with LbCas12a-induced mutations in 6 clade A type 2C protein phosphatase genes.Plant physiology · 2025Article
- DOG1 controls dormancy independently of ABA core signaling kinases regulation by preventing AFP dephosphorylation through AHG1.Science advances · 2025Article
- The critical roles of three sugar-related proteins (HXK, SnRK1, TOR) in regulating plant growth and stress responses.Horticulture research · 2024Article
- Employing Genomic Tools to Explore the Molecular Mechanisms behind the Enhancement of Plant Growth and Stress Resilience Facilitated by aInternational journal of molecular sciences · 2024Article
- Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1.Science advances · 2024Article
- ABA INSENSITIVE 2 promotes flowering by inhibiting OST1/ABI5-dependent FLOWERING LOCUS C transcription in Arabidopsis.Journal of experimental botany · 2024Article
- A transposon insertion in the promoter of OsUBC12 enhances cold tolerance during japonica rice germination.Nature communications · 2024Article
- Autophagy and Symbiosis: Membranes, ER, and Speculations.International journal of molecular sciences · 2024Review
71 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant survival under environmental stress requires the integration of multiple signaling pathways into a coordinated response, but the molecular mechanisms underlying this integration are poorly understood. Stress-derived energy deprivation activates the Snf1-related protein kinases1 (SnRK1s), triggering a vast transcriptional and metabolic reprogramming that restores homeostasis and promotes tolerance to adverse conditions. Here, we show that two clade A type 2C protein phosphatases (PP2Cs), established repressors of the abscisic acid (ABA) hormonal pathway, interact with the SnRK1 catalytic subunit causing its dephosphorylation and inactivation. Accordingly, SnRK1 repression is abrogated in double and quadruple pp2c knockout mutants, provoking, similarly to SnRK1 overexpression, sugar hypersensitivity during early seedling development. Reporter gene assays and SnRK1 target gene expression analyses further demonstrate that PP2C inhibition by ABA results in SnRK1 activation, promoting SnRK1 signaling during stress and once the energy deficit subsides. Consistent with this, SnRK1 and ABA induce largely overlapping transcriptional responses. Hence, the PP2C hub allows the coordinated activation of ABA and energy signaling, strengthening the stress response through the cooperation of two key and complementary pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.