Evidence map›Paper›PMID 24178976›Full record

Trial reportClinical journal of the American Society of Nephrology : CJASN2014

Association between GFR estimated by multiple methods at dialysis commencement and patient survival.

Muh Geot Wong, Carol A Pollock, Bruce A Cooper, Pauline Branley, John F Collins, Jonathan C Craig, Joan Kesselhut, Grant Luxton, Andrew Pilmore, David C Harris and 1 more

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Peritoneal dialysis versus haemodialysis for people commencing dialysis.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. The Impact of Timing of Dialysis Initiation on Mortality in Patients with Peritoneal Dialysis.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2015
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Muh Geot WongDepartment of Renal Medicine, Royal North Shore Hospital, Sydney Medical School, University of Sydney, Sydney, Australia;, †Monash Medical Centre and Eastern Health Renal Units, Melbourne, Australia;, ‡Department of Renal Medicine, Auckland City Hospital, Auckland, New Zealand;, §Department of Nephrology, Children's Hospital at Westmead, Sydney School of Public Health, University of Sydney, Sydney, Australia;, ‖Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia;, ¶Centre for Transplantation and Renal Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia, *Centre for Kidney Disease Research, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
Carol A Pollock
Bruce A Cooper
Pauline Branley
John F Collins
Jonathan C Craig
Joan Kesselhut
Grant Luxton
Andrew Pilmore
David C Harris
David W Johnson
The University of Sydney · AUAuckland City Hospital · NZChildren's Hospital at Westmead · AUEastern Health · AUPrincess Alexandra Hospital · AURoyal North Shore Hospital · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe Initiating Dialysis Early and Late study showed that planned early or late initiation of dialysis, based on the Cockcroft and Gault estimation of GFR, was associated with identical clinical outcomes. This study examined the association of all-cause mortality with estimated GFR at dialysis commencement, which was determined using multiple formulas. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Initiating Dialysis Early and Late trial participants were stratified into tertiles according to the estimated GFR measured by Cockcroft and Gault, Modification of Diet in Renal Disease, or Chronic Kidney Disease-Epidemiology Collaboration formula at dialysis commencement. Patient survival was determined using multivariable Cox proportional hazards model regression.

resultsOnly Initiating Dialysis Early and Late trial participants who commenced on dialysis were included in this study (n=768). A total of 275 patients died during the study. After adjustment for age, sex, racial origin, body mass index, diabetes, and cardiovascular disease, no significant differences in survival were observed between estimated GFR tertiles determined by Cockcroft and Gault (lowest tertile adjusted hazard ratio, 1.11; 95% confidence interval, 0.82 to 1.49; middle tertile hazard ratio, 1.29; 95% confidence interval, 0.96 to 1.74; highest tertile reference), Modification of Diet in Renal Disease (lowest tertile hazard ratio, 0.88; 95% confidence interval, 0.63 to 1.24; middle tertile hazard ratio, 1.20; 95% confidence interval, 0.90 to 1.61; highest tertile reference), and Chronic Kidney Disease-Epidemiology Collaboration equations (lowest tertile hazard ratio, 0.93; 95% confidence interval, 0.67 to 1.27; middle tertile hazard ratio, 1.15; 95% confidence interval, 0.86 to 1.54; highest tertile reference).

conclusionEstimated GFR at dialysis commencement was not significantly associated with patient survival, regardless of the formula used. However, a clinically important association cannot be excluded, because observed confidence intervals were wide.

Indexed as

Glomerular Filtration RateModels, BiologicalRenal DialysisAustraliaHumansKaplan-Meier EstimateKidneyKidney DiseasesMultivariate AnalysisPredictive Value of TestsProportional Hazards ModelsRisk FactorsTime FactorsTreatment Outcome

Identifiers

PMID24178976
PMCPMC3878691
OpenAlexW2119154902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.