Evidence map›Paper›PMID 24178973›Full record

ReviewClinical journal of the American Society of Nephrology : CJASN2014

Principles of separation: indications and therapeutic targets for plasma exchange.

Mark E Williams, Rasheed A Balogun

Abstract readReview
In one paragraph

Review in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Therapeutic plasma exchange without anticoagulation: Single-center experience.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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  7. Review
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  14. Review
  15. Tropical medicine and infectious disease · 2023
    Review
  16. Article
  17. Review
  18. Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mark E WilliamsRenal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, †Division of Nephrology, University of Virginia, Charlottesville, Virginia.
Rasheed A Balogun

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracorporeal "blood purification," mainly in the form of hemodialysis has been a major portion of the clinical activity of many nephrologists for the past 5 decades. A possibly older procedure, therapeutic plasma exchange, separates and then removes plasma as a method of removing pathogenic material from the patient. In contrast to hemodialysis, therapeutic plasma exchange preferentially removes biologic substances of high molecular weight such as autoantibodies or alloantibodies, antigen-antibody complexes, and Ig paraproteins. These molecular targets may be cleared through two alternative procedures: centrifugal separation and membrane separation. This review presents operational features of each procedure, with relevance to the nephrologist. Kinetics of removal of these plasma constituents are based on the principles of separation by the apheresis technique and by features specific to each molecular target, including their production and compartmentalization in the body. Molecular targets for common renal conditions requiring therapeutic plasma exchange are also discussed in detail.

Indexed as

AntibodiesBiomarkersBlood Component RemovalCentrifugationHumansKidney DiseasesNephrologyPlasma ExchangeTreatment OutcomeAntibodiesBiomarkers

Identifiers

PMID24178973
PMCPMC3878701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.