SynthesisTechniques in coloproctology2014
Clostridium difficile: epidemiology, diagnostic and therapeutic possibilities-a systematic review.
Synthesis in Techniques in coloproctology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Trends in Clostridioides difficile infection prevalence among pediatric cancer patients: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Mechanistic Insights Into the Inhibition ofScientifica · 2026Article
- Therapeutics involved in managing initial and recurrentWorld journal of gastrointestinal pharmacology and therapeutics · 2024Review
- Antibiotic resistance of enteropathogenic bacteria in a teaching hospital in North Khuzestan during a three-year period.Journal of family medicine and primary care · 2024Article
- Article
- A Case ofInfectious diseases & clinical microbiology · 2022Article
- Evaluation of at-home methods for N95 filtering facepiece respirator decontamination.Scientific reports · 2021Article
- An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety.Molecules (Basel, Switzerland) · 2020Review
- Clostridium difficile, the Difficult "Kloster" Fuelled by Antibiotics.Current microbiology · 2019Review
- Controlled Delivery of Vancomycin via Charged Hydrogels.PloS one · 2016Article
- Epidemiology of Clostridium difficile infection: results of a hospital-based study in Krakow, Poland.Epidemiology and infection · 2015Article
- Dentists, antibiotics and Clostridium difficile-associated disease.British dental journal · 2015Review
- Burden of Clostridium difficile infection between 2010 and 2013: Trends and outcomes from an academic center in Eastern Europe.World journal of gastroenterology · 2015Article
- WSES guidelines for management of Clostridium difficile infection in surgical patients.World journal of emergency surgery : WJES · 2015Review
- Clostridium difficile Infection: Epidemiology, Pathogenesis, Risk Factors, and Therapeutic Options.Scientifica · 2014Review
- 2019 update of the WSES guidelines for management ofWorld journal of emergency surgery : WJESReview
- Article
- Tacrolimus Therapy for Three Patients with Elderly-Onset Ulcerative Colitis: Report of Three Cases.Case reports in gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This literature review looks at the epidemiology, clinical manifestations, diagnostics and current medical and surgical management of Clostridium difficile (C. difficile) infection. A literature search of PubMed and Cochrane database regarding C. difficile infection was performed. Information was extracted from 43 published articles from 2000 to the present day which met inclusion criteria. C. difficile is a gram-positive, anaerobic bacillus, which is widely found in the environment, especially in the soil. The occurrence of more resistant strains, which is mainly connected with the wide use of antibiotics, resulted in the rapid spread of the bacteria to different hospital departments. Particularly, elderly patients in surgical wards and intensive care units are at significant risk of developing C. difficile infection, which greatly increases morbidity and mortality. Symptoms of infection with C. difficile vary greatly. At one end of the spectrum, there are asymptomatic carriers, at the other patients with life-threatening toxic megacolon. Metronidazole is considered to be the drug of choice, but recent guidelines recommend Vancomycin. Fulminant colitis and toxic megacolon warrant surgical intervention. The optimal time for surgery is within 48 h of initiating conservative treatment without seeing a response, the development of multiple organ failure or a bowel perforation. A factor that has become increasingly important and relevant is the escalating expense of treatment for patients with C. difficile infection. It is, therefore, highly recommended to consider reviewing all hospital antibiotic policies and clinical guidelines that may contribute to the prevention of the infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.