ArticleLasers in medical science2014
Photodynamic antimicrobial chemotherapy (PACT) inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability.
Article in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Antibiofilm efficacy of 1,064-nm neodymium-doped yttrium aluminum garnet laser onMicrobiology spectrum · 2026Article
- Assessment of the Impact of Antimicrobial Photodynamic Therapy Using a 635 nm Diode Laser and Toluidine Blue on the Susceptibility of Selected Strains ofMicroorganisms · 2025Article
- Light-activated antimicrobial coatings: the great potential of organic photosensitizers.RSC advances · 2025Review
- Efficiency of the photodynamic therapy on viability of Streptococcus mutans in the oral cavity using chitosan nanoparticles: an in vitro study.Lasers in medical science · 2024Article
- Potential Anti-International journal of molecular sciences · 2023Article
- Nanoparticle-Based Photodynamic Inhibition ofACS omega · 2023Article
- Inhibitory Effects and Mechanism of Action of Elsinochrome A onJournal of fungi (Basel, Switzerland) · 2022Article
- Photosensitizers Mediated Photodynamic Inactivation against Fungi.Nanomaterials (Basel, Switzerland) · 2021Review
- Influence of Incubation Time on Ortho-Toluidine Blue Mediated Antimicrobial Photodynamic Therapy Directed against SelectedInternational journal of molecular sciences · 2021Article
- Efficacy of Toluidine Blue-Mediated Antimicrobial Photodynamic Therapy onAntibiotics (Basel, Switzerland) · 2021Review
- Photodynamic Antimicrobial Action of Asymmetrical Porphyrins Functionalized Silver-Detonation Nanodiamonds Nanoplatforms for the Suppression ofFrontiers in chemistry · 2021Article
- Inhibitory Effects of Photodynamic Inactivation on Planktonic Cells and Biofilms of Candida auris.Mycopathologia · 2019Article
- Review
- Photodynamic antimicrobial chemotherapy (PACT) using toluidine blue inhibits both growth and biofilm formation by Candida krusei.Lasers in medical science · 2018Article
- Biofilm formation by Candida albicans is inhibited by photodynamic antimicrobial chemotherapy (PACT), using chlorin e6: increase in both ROS production and membrane permeability.Lasers in medical science · 2018Article
- Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections.Frontiers in microbiology · 2018Review
- Review
- Virulence factors of fluconazole-susceptible and fluconazole-resistant Candida albicans after antimicrobial photodynamic therapy.Lasers in medical science · 2017Article
- Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation.BMC cancer · 2016Article
- Action of antimicrobial photodynamic therapy on heterotypic biofilm: Candida albicans and Bacillus atrophaeus.Lasers in medical science · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The opportunistic fungal Candida albicans is able to produce both superficial and systemic infections in immunocompromised patients. Photodynamic antimicrobial chemotherapy (PACT) is a process that combines visible light and a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells and has been presented as a potential antimicrobial therapy. In this work, we study the effects of PACT, using toluidine blue (TB) as a photosensitizer drug, on ROS production and cell damage and the ability of C. albicans to form biofilm. A significant decrease was observed in the cell growth after PACT in a TB concentration-dependent manner. This effect was dependent on the incubation time after PACT. In addition, an increase in both the ROS production and cell permeability, after PACT, in a TB concentration-dependent manner was observed. PACT, using 0.1 mg/ml TB was able to reduce biofilm formation in 30, 50, and 62%, in cells submitted to incubation times of 1, 2, and 3 h, respectively. These results suggested that PACT, using TB, is able to decrease both growth and biofilm formation by C. albicans, possibly by a mechanism evolving both ROS production and the increase in the cell permeability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.