ReviewJournal of medical toxicology : official journal of the American College of Medical Toxicology2013
The role of chelation in the treatment of arsenic and mercury poisoning.
Review in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 136 citations in OpenAlex.
- Acrodynia and CASPR2 Autoimmunity in Elemental Mercury Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026Article
- Inhalation arsine poisoning: clinical features and treatment experience of 12 cases from a single incident.BMC pharmacology & toxicology · 2026Article
- Heavy Metal Toxicity in Clinical and Environmental Health: Sources, Mechanisms, Diagnostics, and Evidence-Based Management of Mercury, Lead, Cadmium, and Arsenic.International journal of molecular sciences · 2026Review
- The use of minerals, plants and burnt materials in ancient medicine: Approaches to working recipes in John the Physician'sProceedings of the Geologists' Association. Geologists' Association · 2026Article
- Mercury in Retrograde: The Tale of Toxicity.Case reports in nephrology · 2026Article
- Arsenome, Arsenobolome, and Arsenobiolome.International journal of molecular sciences · 2025Review
- Article
- Review
- A Diagnostic and Management Challenge in Severe Fatal Mercury Poisoning Secondary to Homeopathic Medications.Cureus · 2025Article
- An engineered gut bacterium protects against dietary methylmercury exposure in pregnant mice.Cell host & microbe · 2025Article
- Toxic effects of chronic occupational mercury vapor exposure on female workers of childbearing age.Journal of occupational medicine and toxicology (London, England) · 2025Article
- Article
- A case of arsenic poisoning caused by local injections in the breast.World journal of emergency medicine · 2024Article
- Article
- Influence of heavy metals in Parkinson's disease: an overview.Journal of neurology · 2022Review
- Natural Dietary Compounds in the Treatment of Arsenic Toxicity.Molecules (Basel, Switzerland) · 2022Review
- Mutagenic, Carcinogenic, and Teratogenic Effect of Heavy Metals.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Mercury and Mercury-Containing Preparations: History of Use, Clinical Applications, Pharmacology, Toxicology, and Pharmacokinetics in Traditional Chinese Medicine.Frontiers in pharmacology · 2022Review
- Quercetin Zinc and Iron Metal Complexes Protect against Sodium Arsenite Intoxication in the Hepato-Renal System of Wistar Rats via the Oxidative Stress Pathway.Journal of toxicology · 2022Article
- Characteristics and treatment of elemental mercury intoxication: A case series.Health science reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Chelation for heavy metal intoxication began more than 70 years ago with the development of British anti-lewisite (BAL; dimercaprol) in wartime Britain as a potential antidote the arsenical warfare agent lewisite (dichloro[2-chlorovinyl]arsine). DMPS (unithiol) and DMSA (succimer), dithiol water-soluble analogs of BAL, were developed in the Soviet Union and China in the late 1950s. These three agents have remained the mainstay of chelation treatment of arsenic and mercury intoxication for more than half a century. Animal experiments and in some instances human data indicate that the dithiol chelators enhance arsenic and mercury excretion. Controlled animal experiments support a therapeutic role for these chelators in the prompt treatment of acute poisoning by arsenic and inorganic mercury salts. Treatment should be initiated as rapidly as possible (within minutes to a few hours), as efficacy declines or disappears as the time interval between metal exposure and onset of chelation increases. DMPS and DMSA, which have a higher therapeutic index than BAL and do not redistribute arsenic or mercury to the brain, offer advantages in clinical practice. Although chelation following chronic exposure to inorganic arsenic and inorganic mercury may accelerate metal excretion and diminish metal burden in some organs, potential therapeutic efficacy in terms of decreased morbidity and mortality is largely unestablished in cases of chronic metal intoxication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.